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. 2022 Jul 22;12:931023. doi: 10.3389/fonc.2022.931023

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Copyright © 2022 Wiedemann, Coppes and van Luijk

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Currently approved treatments for PAH (right side) include ER-antagonists, prostacyclin analogs, PDE5-inhibitors and sGC stimulators which inhibit vasoconstriction and proliferation or act vasodilative and anti-proliferative to reduce blood pressure and inhibit vascular remodeling. Potential novel treatment options (left side) like senolytics or tyrosine kinase receptor inhibitors inhibit vascular remodeling. The treatment with patient-derived endothelial progenitor cells can maintain vessel integrity.