Table 1.
Summery of preclinical animal studies showing evidence that vascular remodeling after irradiation of the lung can lead to cardiotoxicity.
| Reference | Animal model | Irradiation modalities and dose | Irradiation field | Time points |
|---|---|---|---|---|
| Molthen et al., 2012 (15) | Female WAG/Rij/Cmcr rats | Photons, 10 Gy | Whole thorax | 2 month after irradiation |
| Gosh et al., 2019 (16) | Female WAG/Rij/MCW rats | Photons, 10Gy | Whole thorax | Up to 12 month after irradiation |
| McChesney-Gilette et al., 1991 (18) | Adult beagle dogs, 1 year old | Photons, 12 Gy | Group I: entire heart and lung Group II: lung only, heart shielded Group III: entire heart+ overlying lung |
Up to 24 weeks |
| Ghobadi et al., 2012 (19) | Adult male albino Wistar rats | Protons, 20Gy | 33% lateral lung 50% lateral lung Lung excluding heart Heart+lung |
8 weeks |
| Ghobadi et al., 2012 (20) | Adult male albino Wistar rats | Protons, 20Gy | Heart+ 25% lung Heart+ 50% lung 50% lung |
8 weeks |