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. 2022 Jul 11;146(6):450–462. doi: 10.1161/CIRCULATIONAHA.122.059150

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© 2022 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 3. — Changes in plasma renin concentration, urine 8-isoprostane, and urine cyclic guanosine monophosphate during screening subtracted from randomization and placebo subtracted from empagliflozin in patients with type 1 diabetes at baseline and in response to ramipril treatment after addition of empagliflozin or placebo. Changes in (A) plasma renin concentration, (B) urine 8-isoprostane, and (C) urine cyclic guanosine monophosphate during screening subtracted from randomization and placebo subtracted from empagliflozin in patients with type 1 diabetes at baseline and in response to ramipril treatment after addition of empagliflozin or placebo.