Table 3.
Characteristics of the included studies that explored the prognostic value of TREM-1 expression in neonatal sepsis.
| References | Country | No. | Survivors/non- survivors ( n ) | Study design | Type of sample | Onset | Biomarkers | Assay method | Cut-off | Sensitivity/ specificity (%) | TP | FP | FN | TN | AUC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adly et al. (39) | Egypt | 63 | 47/16 | Prospective | Serum | EOS+LOS | sTREM-1 | ELISA | 1,100 Pg /ml | 100/97 | 47 | 0 | 0 | 16 | 0.978 |
| El-Gendy et al. (41) | Egypt | 40 | 23/17 | Case-control | Serum | N/A | sTREM-1 | ELISA | 2,902.2 Pg/ml | 88.2/78.3 | 20 | 4 | 3 | 13 | 0.92 |
| Arízaga-Ballesteros et al. (40) | Mexico | 71 | 62/9 | Cross-sectional | Plasma | LOS | sTREM-1 | ELISA | 300 Pg/ml | 97/78 | 60 | 2 | 2 | 7 | 0.884 |
| El-Khier et al. (43) | Egypt | 30 | 27/3 | Prospective | Serum | LOS | sTREM-1 | ELISA | 91.5 Pg /ml | 96.3/100 | 26 | 0 | 1 | 3 | 0.988 |
| Ghonaim et al. (48) | Egypt | 75 | 34/41 | Case-control | Whole blood | EOS+LOS | TREM-1 mRNA | RT-PCR | 0.369 | 87.8/97.06 | 30 | 1 | 4 | 40 | 0.902 |
TREM-1, triggering receptor expressed on myeloid cell-1; sTREM-1, soluble triggering expressed receptor on myeloid cells-1; ELISA, enzyme-linked immunosorbent assay; RT-PCR, reverse transcription-polymerase chain reaction; TP, true positives; FP, false positives; FN, false negatives; TN, true negatives; AUC, area under the curve; N/A, not applicable; No, number.