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. 2022 Jul 22;13:914884. doi: 10.3389/fmicb.2022.914884

Figure 1.

Figure 1

Virulence level of different bacterial strains. (A) Mucoviscosity and (B) uronic acid production for different K. pneumoniae strains. Each data point was repeated three times (n = 3). Data represent mean ± SEM. Unpaired two-sided Student's t-test was performed for strains EH12PC-TC vs. EH12PC (P < 0.0001), PM8PC-TC vs. PM8PC (P < 0.0001), and 14WZ-1-TC vs. 14WZ-1 (P < 0.0001). Survival of mice (n = 8) infected by 5 × 103 CFU (C) and 1 × 103 CFU (D) of each K. pneumoniae strain at 168 hrs. The test strains included the K. pneumoniae strain PM27, virulence plasmid-cured ST23-KL1 K. pneumoniae strain EH12PC, transconjugant strain EH12PC-TC, HvKP strain HvKP1088 (hypervirulence control), and the classic CRKP strain FJ8 (low-virulence control). The log-rank (Mantel–Cox) test was performed for curves of strains EH12PC and EH12PC-TC. A significant difference (P = 0.0069 and 0.0401 at an inoculum of 5 × 103 and 1 × 103 CFU, respectively) was observed between curves.