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. 2022 Jul 22;12:942341. doi: 10.3389/fonc.2022.942341

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© 2022 Digiacomo, Fumarola, La Monica, Bonelli, Cavazzoni, Galetti, Terenziani, Eltayeb, Volta, Zoppi, Bertolini, Missale, Alfieri and Petronini

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of the simultaneous combination of abemaciclib and lenvatinib on intracellular signaling pathways. Cells were treated with 1 μM A and 0.5, 2, or 6.5 μM L for HUH7, SNU398, and HepG2, respectively, alone or in combination for 24 h. The cells were lysed and the expression of the indicated proteins was evaluated by Western blot analysis. Data are representative of two independent experiments.