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. 2022 Jul 22;15:975820. doi: 10.3389/fnmol.2022.975820

FIGURE 1.

FIGURE 1

The effects of 3-MMC on CPP and locomotor activity. (A) Experimental timeline showing the CPP training. The rats trained with saline, METH (1 mg/kg) or 3-MMC (1, 3, or 10 mg/kg) for 8 days and tested in day 9, paired t-test, *P < 0.05, **P < 0.01 significant differences for each drug in CPP test, n = 10 for each group. (B) A single injection of 3-MMC (3 mg/kg) or METH (1 mg/kg) increased locomotor activity. Each point represents the average distance traveled in 5-min bins. Saline, Meth and 3-MMC group, post hoc test, *P < 0.05 significant differences in distance for 3-MMC vs saline, #P < 0.05 significant differences for METH vs saline, n = 8, 9, and 8, respectively. Data are presented as mean values ± SEM.