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. 2022 Jul 22;15:975820. doi: 10.3389/fnmol.2022.975820

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Copyright © 2022 Chen, Zhang, Ding, Wu, Wang and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Specific brain regions response to chronic 3-MMC exposure. (A) The c-Fos expression of rats 90 min after last injection of drugs, post hoc test, *P < 0.05, **P < 0.01 significant differences for 3-MMC vs saline or METH vs saline, ^#P < 0.05 significant differences for 3-MMC vs METH, n = 4 for each group. (B) Representative immunofluorescent images of c-Fos expression in ACC, NAc, and VTA. Scale bar, 100 μm. ACC, anterior cingulate cortex; PrL, prelimbic cortex; IL, infralimbic cortex; OFC, orbitofrontal cortex; aIC, anterior insular cortex; NAc, nucleus accumbens; DS, dorsal striatum; BLA, basolateral amygdala; CeA, central amygdala; VTA, ventral tegmental area. Data are presented as mean values ± SEM.