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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2022 Jun 1;31(6):1216–1226. doi: 10.1158/1055-9965.EPI-21-1008

Table 2.

Stratified analysis by sex and age in individuals of European descent

Female
 Male
 Age at diagnosis < 50 yrs
 Age at diagnosis ≥ 50 yrs
Metabolite OR (95CI) P OR (95%CI) P P het OR (95CI) P OR (95CI) P P het
C38:4 PC 1.02 (1.01-1.03) 4.51x10−4 1.02 (1.01-1.03) 2.62x10−5 0.757 1.002 (0.998-1.005) 0.353 1.02 (1.01-1.03) 3.45x10−8 3.45x10−6
C20:4 CE 1.03 (1.01-1.05) 2.63x10−4 1.03 (1.02-1.05) 8.15x10−5 0.987 1.001 (0.996-1.006) 0.711 1.03 (1.02-1.05) 5.55x10−8 1.61x10−6
C36:4 PC 1.02 (1.01-1.04) 4.62x10−4 1.02 (1.01-1.04) 1.10x10−4 0.929 1.002 (0.997-1.006) 0.470 1.03 (1.02-1.03) 1.29x10−7 6.32x10−6
C34:2 PC 0.91 (0.86-0.97) 0.002 0.90 (0.86-0.95) 7.93x10−5 0.714 0.992 (0.975-1.009) 0.354 0.91 (0.87-0.94) 3.19x10−7 1.95x10−5
C38:5 PC 1.03 (1.01-1.05) 7.72x10−4 1.04 (1.02-1.05) 1.20x10−4 0.861 1.002 (0.996-1.008) 0.560 1.04 (1.02-1.05) 2.09x10−7 7.06x10−6
C20:4 LPC 1.03 (1.01-1.04) 9.33x10−4 1.03 (1.01-1.04) 1.55x10−4 0.865 1.002 (0.998-1.007) 0.344 1.03 (1.02-1.04) 5.21x10−7 2.89x10−5
C22:6 LPC 1.05 (1.02-1.09) 0.002 1.07 (1.03-1.10) 5.53x10−5 0.588 1.003 (0.993-1.014) 0.511 1.06 (1.04-1.08) 4.92x10−7 1.62x10−5
C40:6 PC 1.05 (1.02-1.09) 0.002 1.06 (1.03-1.10) 1.19x10−4 0.734 1.002 (0.992-1.013) 0.670 1.06 (1.04-1.09) 4.20x10−7 9.30x10−6
C20:5 LPC 1.02 (1.01-1.04) 0.011 1.04 (1.02-1.05) 1.15x10−5 0.257 1.004 (0.998-1.009) 0.187 1.03 (1.02-1.04) 1.95x10−6 1.44x10−4
C20:5 CE 1.05 (1.02-1.09) 9.55x10−4 1.05 (1.02-1.09) 3.55x10−4 0.976 1.003 (0.993-1.013) 0.571 1.06 (1.03-1.08) 7.88x10−6 1.97x10−5
C58:11 TAG 1.05 (1.02-1.08) 0.001 1.05 (1.02-1.08) 4.34x10−4 0.947 1.004 (0.995-1.013) 0.387 1.05 (1.03-1.07) 1.70x10−6 6.18x10−5
C18:2 LPE 0.96 (0.94-0.99) 0.002 0.96 (0.94-0.98) 6.60x10−4 0.942 1.002 (0.994-1.010) 0.634 0.96 (0.94-0.97) 1.11x10−6 3.56x10−6
C36:2 PC 0.93 (0.88-0.98) 0.004 0.92 (0.88-0.97) 0.001 0.927 1.001 (0.985-1.017) 0.935 0.92 (0.89-0.95) 5.92x10−6 3.16x10−5
C20:4 LPE 1.04 (1.01-1.06) 0.002 1.03 (1.01-1.05) 0.011 0.581 1.003 (0.995-1.010) 0.463 1.03 (1.02-1.05) 7.13x10−5 9.24x10−4
C58:10 TAG 1.02 (1.01-1.04) 0.011 1.03 (1.01-1.04) 0.004 0.920 1.003 (0.998-1.009) 0.246 1.02 (1.01-1.04) 3.29x10−4 0.005
C50:4 TAG 0.96 (0.92-1.00) 0.054 0.94 (0.91-0.98) 0.002 0.491 0.986 (0.974-0.998) 0.027 0.96 (0.93-0.98) 0.002 0.058
lactate 0.97 (0.95-1.00) 0.024 0.97 (0.95-1.00) 0.024 0.733 0.993 (0.986-1.001) 0.100 0.97 (0.96-0.99) 0.003 0.037
alanine 0.96 (0.93-1.00) 0.055 0.95 (0.92-0.99) 0.008 0.705 0.988 (0.976-1.000) 0.052 0.96 (0.94-0.99) 0.007 0.095
C48:3 TAG 0.97 (0.93-1.00) 0.082 0.95 (0.92-0.98) 0.002 0.403 0.988 (0.977-0.999) 0.036 0.96 (0.94-0.99) 0.003 0.073
C32:2 PC 0.96 (0.92-1.00) 0.065 0.95 (0.91-0.98) 0.005 0.591 0.988 (0.975-1.000) 0.052 0.96 (0.94-0.99) 0.004 0.074
α-hydroxybutyrate 0.98 (0.96-1.00) 0.095 0.97 (0.96-0.99) 0.008 0.561 0.996 (0.990-1.002) 0.198 0.98 (0.97-0.99) 0.006 0.047
C48:2 TAG 0.98 (0.95-1.01) 0.194 0.96 (0.93-0.99) 0.007 0.387 0.991 (0.981-1.001) 0.064 0.98 (0.95-1.00) 0.019 0.171
C20:3 LPC 0.95 (0.92-0.99) 0.011 0.98 (0.95-1.01) 0.273 0.266 0.999 (0.988-1.010) 0.824 0.97 (0.95-0.99) 0.010 0.023
C50:3 TAG 0.98 (0.95-1.02) 0.298 0.96 (0.94-1.00) 0.023 0.434 0.992 (0.982-1.003) 0.148 0.98 (0.96-1.00) 0.052 0.243
C16:0 CE 1.02 (0.98-1.05) 0.424 1.01 (0.98-1.05) 0.471 0.927 0.997 (0.985-1.009) 0.607 1.02 (0.99-1.05) 0.128 0.110