. Author manuscript; available in PMC: 2022 Dec 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2022 Jun 1;31(6):1216–1226. doi: 10.1158/1055-9965.EPI-21-1008

Table 3.

Stratified analysis by sex and age in individuals of Asian descent

	Female		Male		Age at diagnosis < 50 yrs		Age at diagnosis ≥ 50 yrs
Metabolite	OR (95CI)	P	OR (95%CI)	P	OR (95CI)	P	OR (95CI)	P
C38:4 PC	1.16 (1.07-1.26)	6.14x10⁻⁴	1.15 (1.05-1.26)	0.002	1.17 (1.02-1.35)	0.022	1.15 (1.08-1.23)	4.92x10⁻⁵
C20:4 CE	0.97 (0.71-1.33)	0.853	1.27 (0.92-1.75)	0.154	0.93 (0.56-1.54)	0.773	1.11 (0.86-1.42)	0.437
C36:4 PC	1.21 (1.09-1.35)	5.03x10⁻⁴	1.19 (1.06-1.34)	0.003	1.27 (1.06-1.51)	0.009	1.19 (1.09-1.30)	1.00x10⁻⁴
C38:5 PC	1.34 (1.14-1.57)	4.32x10⁻⁴	1.31 (1.11-1.56)	0.002	1.40 (1.08-1.82)	0.011	1.31 (1.15-1.49)	4.19x10⁻⁵
C20:4 LPC	1.24 (1.10-1.40)	5.95x10⁻⁴	1.23 (1.08-1.40)	0.002	1.27 (1.04-1.55)	0.018	1.23 (1.12-1.36)	3.78x10⁻⁵
C22:6 LPC	1.64 (1.23-2.19)	7.78x10⁻⁴	1.63 (1.20-2.22)	0.002	1.78 (1.12-2.84)	0.015	1.62 (1.28-2.04)	5.21x10⁻⁵
C40:6 PC	1.63 (1.23-2.15)	6.17x10⁻⁴	1.61 (1.20-2.17)	0.002	1.74 (1.11-2.73)	0.016	1.61 (1.29-2.02)	2.87x10⁻⁵
C20:5 LPC	1.26 (1.09-1.46)	0.002	1.31 (1.12-1.53)	7.76x10⁻⁴	1.40 (1.10-1.77)	0.007	1.26 (1.12-1.42)	1.30x10⁻⁴
C20:5 CE	1.63 (1.25-2.14)	3.74x10⁻⁴	1.57 (1.18-2.09)	0.002	1.76 (1.13-2.72)	0.012	1.58 (1.27-1.96)	4.17x10⁻⁵
C58:11 TAG	1.59 (1.23-2.04)	3.14x10⁻⁴	1.53 (1.17-1.99)	0.002	1.71 (1.14-2.57)	0.009	1.53 (1.25-1.87)	3.88x10⁻⁵
C18:2 LPE	0.75 (0.62-0.91)	0.004	0.73 (0.59-0.90)	0.003	0.71 (0.52-0.98)	0.035	0.74 (0.63-0.87)	1.72x10⁻⁴
C36:2 PC	0.35 (0.20-0.62)	3.16x10⁻⁴	0.38 (0.21-0.70)	0.002	0.31 (0.12-0.79)	0.014	0.37 (0.24-0.59)	3.07x10⁻⁵
C20:4 LPE	1.39 (1.12-1.72)	0.003	1.44 (1.15-1.80)	0.002	1.45 (1.03-2.05)	0.032	1.40 (1.18-1.66)	1.09x10⁻⁴
C58:10 TAG	1.32 (1.10-1.59)	0.003	1.35 (1.11-1.64)	0.002	1.42 (1.06-1.91)	0.020	1.33 (1.14-1.54)	1.76x10⁻⁴
C50:4 TAG	0.83 (0.55-1.24)	0.358	0.72 (0.47-1.10)	0.130	0.74 (0.39-1.41)	0.357	0.76 (0.55-1.05)	0.101
Lactate	0.74 (0.53-1.03)	0.073	0.78 (0.55-1.11)	0.164	0.76 (0.45-1.28)	0.305	0.78 (0.60-1.02)	0.069
Alanine	0.72 (0.48-1.08)	0.108	0.73 (0.48-1.12)	0.149	0.59 (0.31-1.13)	0.113	0.77 (0.56-1.07)	0.119
C48:3 TAG	0.92 (0.63-1.34)	0.663	0.74 (0.50-1.10)	0.136	0.85 (0.46-1.54)	0.588	0.80 (0.59-1.08)	0.140
C32:2 PC	0.80 (0.50-1.27)	0.347	0.67 (0.41-1.08)	0.102	0.86 (0.41-1.80)	0.694	0.70 (0.48-1.02)	0.061
α-hydroxybutyrate	0.91 (0.65-1.26)	0.564	0.95 (0.68-1.34)	0.790	1.05 (0.64-1.75)	0.838	0.95 (0.73-1.24)	0.714
C48:2 TAG	0.92 (0.65-1.30)	0.623	0.75 (0.52-1.08)	0.122	0.86 (0.49-1.50)	0.597	0.82 (0.62-1.08)	0.151
C20:3 LPC	0.18 (0.09-0.39)	1.19x10⁻⁵	0.42 (0.19-0.93)	0.031	0.26 (0.08-0.86)	0.028	0.30 (0.16-0.55)	9.57x10⁻⁵
C50:3 TAG	0.79 (0.52-1.22)	0.291	0.73 (0.46-1.15)	0.172	0.85 (0.43-1.69)	0.652	0.75 (0.53-1.06)	0.102
C16:0 CE	1.67 (1.17-2.40)	0.005	1.81 (1.23-2.65)	0.003	1.75 (0.98-3.13)	0.057	1.70 (1.27-2.27)	3.50x10⁻⁴