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. 2022 Jul 22;9:830974. doi: 10.3389/fmed.2022.830974

TABLE 1.

Demographic data, clinical characteristics, incidence of successful and failure weaning in both derivation and validation groups and total population.

Variables Total Population (n = 1,175) Derivation dataset
(n = 208)		 Validation dataset (n = 967) P-value
Gender
Male, N (%)
Female, N (%)
523 (44.5)
652 (55.5)
92 (44.2)
116 (55.8)
431 (44.6)
536 (55.4)
0.929
The cause of admission
Cancer, N (%)
ARDS, N (%)
COPD, N (%)
Multiple traumas, N (%)
Abdominal surgery, N (%)
Pneumonia, N (%)
Sepsis, N (%)
97 (8.3)
216 (18.4)
273 (23.2)
223 (19)
193 (16.4)
119 (10.1)
54 (4.6)
14 (6.7)
39 (18.8)
44 (21.2)
38 (18.3)
38 (18.3)
23 (5.8)
12 (5.8)
83 (8.6)
177 (18.3)
229 (23.7)
185 (19.1)
155 (16)
96 (9.9)
42 (4.3)
0.838
Weaning rate
Successful, N (%)
Unsuccessful, N (%)
939 (79.9)
236 (20.1)
169 (81.3)
39 (18.8)
770 (79.6)
197 (20.4)
0.569
Age, Year, Mean (SD) 58.36 (7.94) 56.19 (9.16) 58.82 (7.57) <0.001
ICU-related variables
ICU LOS, Day, Mean (SD)
Hospital LOS, Day, Mean (SD)
APACHE II, Mean (SD)
SOFA, Mean (SD)
SAPS, Mean (SD)
Hemoglobin, g/dl, Mean (SD)
23.73 (7.96)
13.56 (5.06)
26.43 (4.83)
14.90 (3.86)
49.11 (4.64)
11.13 (1.54)
19.71 (8.17)
12.89 (5.60)
26.35 (5.63)
14.20 (3.01)
48.56 (4.90)
10.98 (1.50)
24.59 (7.64)
13.71 (4.93)
26.44 (4.64)
15.27 (3.92)
49.22 (4.57)
11.17 (1.55)
<0.001
0.034
0.804
0.052
0.060
0.118
Pulmonary-related variables
CDynamic, ml/cmH2O, Mean (SD)
CStatic, ml/cmH2O, Mean (SD)
VE, l/min, Mean (SD)
VT, ml/min, Mean (SD)
RR, breath/min, Mean (SD)
23.39 (3.63)
36.16 (6.42)
7.84 (1.43)
391.31 (40.69)
20.01 (2.82)
23.10 (3.60)
36.94 (5.75)
8.61 (1.75)
422.31 (39.37)
20.34 (3.36)
23.46 (3.64)
35.99 (6.54)
7.67 (1.30)
384.64 (37.79)
19.94 (2.69)
0.192
0.053
<0.001
<0.001
0.063
Gas exchange-related variables
PaO2, mmHg, Mean (SD)
SaO2,%, Mean (SD)
PaCO2, mmHg, Mean (SD)
FiO2,%, Mean (SD)
PALVO2, mmHg, Mean (SD)
PaO2/PALVO2, mmHg, Mean (SD)
P(ALV-a) O2, mmHg, Mean (SD)
88.76 (5.30)
88.89 (1.47)
43.92 (2.73)
35.27 (2.27)
159.86 (14.30)
0.56 (0.06)
71.10 (15.10)
84.31 (3.60)
89.03 (1.56)
43.57 (2.88)
35.39 (2.28)
161.04 (1453)
0.53 (0.05)
76.73 (14.57)
89.72 (5.19)
88.87 (1.45)
44 (2.69)
35.24 (2.26)
159.61 (14.24)
0.57 (0.06)
69.89 (14.95)
<0.001
0.144
0.035
0.404
0.191
<0.001
<0.001
Conventional weaning indices
RSBI, breath/l/min, Mean (SD)
NIF, cmH2O, Mean (SD)
P.01, milli/second, Mean (SD)
90.39 (10.62)
23.72 (2.97)
5.72 (1.91)
92.74 (10.89)
24.63 (2.90)
6.49 (2.34)
89.89 (10.50)
23.53 (2.96)
5.55 (1.76)
<0.001
<0.001
<0.001
New integrated weaning indices
1. (PPR/RSBI*FiO2), Mean (SD)
2. (PPR/RSBI*FiO2*P.01), Mean (SD)
3. (PPR*NIF/RSBI*FiO2), Mean (SD)
4. (PPR*NIF/RSBI*FiO2*P.01), Mean (SD)
5. (NIF/P.01), Mean (SD)
6. (SaO2/P(ALV-a) O2*RSBI*FiO2), Mean (SD)
7. (SaO2/P(ALV-a) O2*RSBI*FiO2*P.01), Mean (SD)
8. (SaO2*NIF/P(ALV-a) O2*RSBI*FiO2), Mean (SD)
9. (SaO2*NIF/P(ALV-a) O2*RSBI*FiO2*P.01), Mean (SD)
10. (SaO2/P(ALV-a) O2*P.01), Mean (SD)
180.28 (40.34)
350.64 (133.86)
426.29 (104.02)
821.33 (305.06)
454.74 (132.84)
430.59 (166.75)
838.89 (424.58)
1016.78 (402.91)
196.23 (96.93)
256.81 (105.24)
164.80 (33.66)
290.46 (117.33)
405.25 (93.04)
712.75 (289.14)
435.52 (162.32)
380.26 (120.34)
669.65 (315.43)
933.82 (306.88)
164.10 (77.03)
214.01 (92.11)
183.62 (40.89)
363.59 (133.71)
430.82 (105.73)
844.68 (303.48)
458.87 (125.32)
441.42 (173.28)
875.29 (436.20)
1034.63 (418.70)
203.14 (99.39)
266.01 (105.65)
<0.001
<0.001
<0.001
<0.001
0.021
<0.001
<0.001
<0.001
<0.001
<0.001

P-values of 0.05 are shown in bold and are considered significant.