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. 2022 Jul 22;12:926352. doi: 10.3389/fcimb.2022.926352

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Copyright © 2022 Moraes, Martins-Gonçalves, Silva, Mandacaru, Melo, Azevedo-Quintanilha, Perales, Bozza, Souza, Castro-Faria-Neto, Hottz, Bozza and Trugilho

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TF-bearing platelet-derived EVs correlates with poor outcome in COVID-19 patients. The percentage of total circulating (A) and platelet derived EVs (B) of COVID-19 survivors and non-survivors. The concentration of TF-bearing platelet-derived EVs (C) and the percentage of platelet-derived EVs expressing TF (D) are shown for covid survivors and non-survivors. Medians with interquartile range are shown. Individual values for COVID-19 survivors (green dots), and COVID-19 non-survivors (red dots) are shown. The blue line and shade indicate the median and interquartile range of the healthy donor. *p<0.05 and **p<0.001.