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. 2022 Jul 22;12:926352. doi: 10.3389/fcimb.2022.926352

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Copyright © 2022 Moraes, Martins-Gonçalves, Silva, Mandacaru, Melo, Azevedo-Quintanilha, Perales, Bozza, Souza, Castro-Faria-Neto, Hottz, Bozza and Trugilho

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathway analysis of C vs COVID-19 proteome. (A) A network of enriched pathway terms from protein lists of DEPs and EPs in the C vs COVID-19 comparison. Nodes that share the same ID are typically close to each other. Pathways database used was WikiPathways, GO Biological Process, KEGG, and Reactome. Red, C; Blue, COVID-12. (B) Protein–protein interaction analysis of DEPs and EPs was performed with STRING, BioGrid, OmniPath, and InWeb_IM databases. Only physical interactions in STRING (physical score >0.132) and BioGrid are used.