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Selective deletion of VGLUT2 from DA neurons blunted locomotor response to METH. A, B: Dose-dependent effects of METH in HET and cKO mice. C: Locomotor response (% baseline) to 0.5 mg/kg METH. D: Locomotor response (% baseline) to 1 mg/kg METH. METH, at 1 mg/kg, increased open-field locomotion in HET, but not in cKO mice. *p < 0.05, **p < 0.01, ***p < 0.001, compared to baseline before METH injection. #p < 0.05, ##p < 0.01, ###p < 0.001, compared to HET group.
