Summary of findings 3. Hydrogel dressings compared with manuka honey for venous leg ulcers healing.
| Hydrogel dressings compared with manuka honey for venous leg ulcer healing | ||||||
| Patient or population: people with venous leg ulcers Setting: hospital and community leg ulcer clinics Intervention: hydrogel dressings Comparison: manuka honey | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with manuka honey | Risk with hydrogel dressings compared with manuka honey | |||||
| Complete wound healing | Study population | RR 0.75 (0.46 to 1.21) | 108 (1 RCT) | ⊕⊝⊝⊝ Very lowa,b | It is uncertain if there is any difference in complete ulcer healing between hydrogel and manuka honey. | |
| 444 per 1000 | 333 per 1000 (204 to 538) | |||||
| Moderate | ||||||
| 333 per 1000 | 250 per 1000 (153 to 403) | |||||
| Incidence of wound infection | Study population | RR 2.00 (0.81 to 4.94) | 108 (1 RCT) | ⊕⊝⊝⊝ Very lowa,b | It is uncertain if there is any difference in wound infection between hydrogel and manuka honey. | |
| 111 per 1000 | 222 per 1000 (90 to 549) | |||||
| Change in ulcer size | Not reported. | |||||
| Time‐to‐ulcer healing | Not reported. | |||||
| Health‐related quality of life | Not reported. | |||||
| Costs | Not reported. | |||||
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RCT: randomised controlled trial; RR: risk ratio. | ||||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | ||||||
aDowngraded twice due to high risk of bias for blinding of participants and personnel, blinding of outcome assessment and unclear risk for other bias. bDowngraded twice for imprecision as the optimal information size was not met and confidence intervals were wide.