Table 1.

Pre-treatment Characteristics (N = 130)

Characteristic	Number (%) or Median [range]
Age, years	63 [36–88]
Age ≥ 65 years	63 (48)
Male sex	88 (68)
Rai stage at diagnosis
0	38 (29)
I-II	78 (60)
III-IV	14 (11)
B2M at diagnosis, mg/L (n=124)	2.8 [0.1–14.3]
B2M >3.5 mg/L	40 (32)
IGHV unmutated (n=119)	95 (80)
TP53 mutated (n=110)	89 (81)
Median TP53 mutation VAF, %	42.6 [1–99.5]
Del(17p) present	104 (80)
Median cells with del(17p), %	58.5 [3.5–99]
Multi-hit TP53 alteration (n=110)	68 (62)
Other FISH abnormalities
Del(13q)	76 (58)
Trisomy 12	29 (22)
Del(11q)	18 (14)
Cytogenetic abnormalities (n=98)	1 [0–22]
≥ 3	41 (42)
≥ 5	33 (34)
Additional mutations (n=75)
NOTCH1	23 (31)
SF3B1	13 (17)
BIRC3	5 (7)

Characteristics captured immediately pretreatment unless specified

B2M, beta 2-microglobulin; IGHV, immunoglobulin heavy chain variable region; VAF, variant allele frequency; del, deletion