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. 2022 Jul 22;13:927046. doi: 10.3389/fgene.2022.927046

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Copyright © 2022 Jiang, Shen, Wei, Chen, Chai, Xia and Leng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identified key genes and their examined prognostic significance. (A) Top 20 genes with the highest correlation to overall survival (OS) are shown. (B) Crossing the 3,429 DEGs with 397 prognosis genes. (C) Kaplan–Meier curve of STC2. (D) Time-dependent receiver operating characteristics (ROC) curves of STC2 for 1, 3, and 5 years (E) STC2 mRNA levels in HNSCC tissues (n = 502) and normal tissues (n = 44). (F) Diagnostic significance of STC2 in HNSCC. ROC curves were plotted and the area under the curve (AUC) of STC2 was 94.7%.