Table 1.

Pa MMR genes and their respective functions, along with common point mutation positions resulting in protein inactivation (Oliver et al., 2002a; Hogardt et al., 2006; On and Welch, 2021).

Gene	Product function	Conserved residues resulting in loss-of-function
mutS	DNA mismatch/short indel recognition	A187, F653, R842, K852
mutL	Endonuclease, nicks daughter strand (methylation-independent)	K307
uvrD	DNA helicase, unwinds double helix to allow for damage removal	A31, G32, G36