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. 2022 Jul 22;9:947778. doi: 10.3389/fmolb.2022.947778

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Copyright © 2022 Liang, Miao, Teng, Xiao, Guo, Xue, Tian, Jin and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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H₂S alleviated myocardial injury and improved cardiac function in rats fed with HID. (A) Representative images of M-mode by echocardiography in HID rats. (B) Values of EF (%) in HID rats. (C) Values of FS (%) in HID rats. (D) Values of +dp/dt_max in HID rats. (E) Values of −dp/dt_max in HID rats. (F) Values of LVEDP in HID rats. (G) Levels of plasma LDH in HID rats. (H) Levels of plasma CK in HID rats. (I) Quantitative data on inflammatory cells in the microscopic field (%) of HID rats. (J) Representative HE-stained myocardial sections of HID rats. (K) Representative Western blots for P53 and P21 expressions in myocardial tissues of HID rats. GAPDH was used as the internal control. (L) Quantitative analysis for the P53 expression in the myocardial tissue of HID rats. (M) Quantitative analysis for the P21 expression in the myocardial tissue of HID rats. Results are means ± SEM. A p-value of <0.05 was considered significant.