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. 2022 Jul 22;9:947778. doi: 10.3389/fmolb.2022.947778

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Copyright © 2022 Liang, Miao, Teng, Xiao, Guo, Xue, Tian, Jin and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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H₂S regulated cardiomyocyte iron metabolism in rats fed with HID. (A) Iron levels in the plasma of HID rats. (B) Iron levels in the myocardial tissue of HID rats. (C) Quantitative data on Prussian-blue staining in HID rats. (D) Representative Prussian-blue staining in myocardial tissue sections of HID rats. (E) Representative Western blots for TFR1, NRF2, FPN1, and FTH expressions in the myocardial tissues of HID rats. GAPDH was used as the internal control. (F) Quantitative analysis for NRF2 expression in the myocardial tissue of HID rats. (G) Quantitative analysis for the TFR1 expression in the myocardial tissue of HID rats. (H) Quantitative analysis for the FPN1 expression in the myocardial tissue of HID rats. (I) Quantitative analysis for the FTH expression in the myocardial tissue of HID rats. Results are means ± SEM. A p-value of <0.05 was considered significant.