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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Nat Synth. 2022 Apr 11;1(5):352–364. doi: 10.1038/s44160-022-00052-1

Fig. 10 |. Dream reactions in single-atom skeletal editing and promising precedents.

Fig. 10 |

a, Wishlist of single-atom editing reactions applied to a complex molecule. b, Examples of the idealized single-atom editing logic in drug discovery shown through carbon-to-nitrogen (left) and nitrogen-to-carbon (right) atom swaps. c, Selected examples of carbon–nitrogen transmutations from Mindola and co-workers81 (top) and Kano and co-workers82 (bottom). d, Representative example of oxygen–nitrogen transmutation78. ‘Edited’ atoms are highlighted for clarity. Cdc7, Cell division cycle 7; PARP, polyadenosine diphosphate ribose polymerase; IC50, half maximal inhibitory concentration; Ki, inhibitory constant.