Table 3.

Meta-analysis results for the 26 genes that are still significantly associated in the primary analyses after adjusting for all lead GWAS hits (0.05/220 = 2.3 x 10^-04).

Chromosome	Gene	P Europeans	P non-Europeans	P meta	χ2 meta	d.f. meta	Adjusted P metaa
1	CEP85	1.98E−06	4.46E−01	1.32E−05	27.88	4	2.90E−03
1	TNFRSF14	4.49E−07	6.19E−01	4.47E−06	30.19	4	9.83E−04
1	E2F2	3.59E−06	1.39E−03	1.00E−07	38.23	4	2.21E−05
1	NDUFS2	7.94E−06	6.19E−02	7.63E−06	29.05	4	1.68E−03
1	ADGRL4	1.02E−07	1.47E−01	2.84E−07	36.04	4	6.24E−05
3	GATA2	1.31E−26	3.64E−01	2.93E−25	121.22	4	6.45E−23
5	OTULINL	1.79E−06	5.01E−01	1.34E−05	27.85	4	2.94E−03
7	ZC3HC1	9.47E−06	1.12E−02	1.82E−06	32.11	4	4.00E−04
9	RMI1	1.45E−07	9.26E−03	2.89E−08	40.85	4	6.35E−06
9	IL33	9.33E−22	2.14E−01	1.02E−20	99.93	4	2.24E−18
9	JAK2	6.92E−08	1.85E−02	2.74E−08	40.96	4	6.04E−06
11	NPAT	3.65E−07	9.16E−02	6.09E−07	34.43	4	1.34E−04
11	PRG3	1.65E−06	1.44E−01	3.85E−06	30.51	4	8.46E−04
12	SH2B3	4.28E−12	1.02E−01	1.29E−11	56.91	4	2.84E−09
15	BCL2A1	2.52E−09	3.44E−01	1.90E−08	41.73	4	4.18E−06
16	EXOC3L1	9.92E−06	1.86E−01	2.62E−05	26.41	4	5.76E−03
16	ZNF668	2.63E−07	3.01E−02	1.55E−07	37.31	4	3.42E−05
16	SOCS1	1.45E−07	3.57E−01	9.18E−07	33.56	4	2.02E−04
17	ALOX15	1.10E−06	9.33E−02	1.75E−06	32.19	4	3.86E−04
17	CTDNEP1	1.00E−06	6.74E−01	1.03E−05	28.42	4	2.26E−03
17	GSDMA	3.26E−06	1.08E−01	5.57E−06	29.72	4	1.23E−03
18	SERPINB11	3.61E−07	1.46E−01	9.36E−07	33.52	4	2.06E−04
19	S1PR4	5.18E−12	2.98E−01	4.36E−11	54.39	4	9.59E−09
19	ARHGAP45	5.74E−07	1.82E−01	1.79E−06	32.14	4	3.94E−04
22	IL17RA	3.09E−10	3.84E−01	2.83E−09	45.71	4	6.23E−07
22	CSF2RB	5.28E−06	3.06E−02	2.69E−06	31.28	4	5.92E−04

^aBonferroni-adjusted P-value adjusting for the 220 significant genes tested.P-values are shown for Europeans (N = 188,248) and non-Europeans (N = 11,372) as well for the meta-analysis, combining the P-values.