Table 4.

Summary of the 18 genes that are significant analyzing rare variants only.

Chromosome	Position	Gene	P-value	Frequency cutoff	N rare variants
2	102,418,689–102,452,565	IL18RAP	2.31E−06	0.3%	269
2	212,999,691–213,152,427	IKZF2	1.45E−08	0.5%	212
3	3,066,324–3,126,613	IL5RA	7.19E−07	0.5%	235
5	131,641,714–131,797,063	FNIP1	4.93E−07	0.5%	445
6	31,268,749–31,272,130	HLA-C	4.84E−07	1%	479
6	31,620,715–31,637,771	PRRC2A	4.14E−07	1%	1,261
6	32,041,153–32,115,334	TNXB	6.99E−08	0.5%	2,043
6	32,517,353–32,530,287	HLA-DRB5	9.02E−07	1%	77
9	4,984,390–5,129,948	JAK2	1.77E−10	0.3%	551
9	6,215,786–6,257,983	IL33	1.17E−34	0.5%	153
12	111,405,923–111,451,623	SH2B3	3.35E−07	0.1%	429
14	23,117,306–23,119,255	CEBPE	7.81E−09	1%	157
15	79,898,840–79,923,702	ST20	1.93E−06	0.5%	23
16	30,934,376–30,960,104	FBXL19	3.36E−07	1%	255
17	4,630,919–4,642,294	ALOX15	4.22E−11	0.1%	364
19	3,172,346–3,180,332	S1PR4	5.12E−17	1%	271
22	17,084,954–17,115,694	IL17RA	6.89E−08	0.5%	532
22	36,913,628–36,940,439	CSF2RB	6.60E−13	0.1%	290

The P-value represents the value corresponding to the lowest frequency cutoff yielding a significant association. Both the allele frequency cutoff and the number of rare variants included in the test are also shown per gene.