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. 2022 Jul 22;13:926175. doi: 10.3389/fimmu.2022.926175

Figure 1.

Figure 1

No detectable inflammatory phenotypes in G87V TRAPS mutant mice under standard housing conditions. (A-D) G87V TRAPS mutant mice were observed until the age of 33 weeks under standard housing conditions. (A) Body weights. (B) Representative histological images of stained tissue sections at 33 weeks of age. The liver, lung, spleen, and inguinal lymph node were stained with hematoxylin and eosin. (C) mRNA expression in the whole blood of the G87V mutant mice at 33 weeks of age (n = 3 each). Whole blood RNA samples were collected by using PAXgene RNA collection tubes. Gene expression levels relative to Hprt were calculated and normalized to the expression level of the WT mice. (D) Serum concentrations of IL-1β were determined by ELISA at 18 and 33 weeks of age. Each dot denotes an individual mouse. Values are presented as means ± standard deviation. TRAPS, Tumor necrosis factor (TNF) receptor-associated periodic syndrome; IL, interleukin; WT, wild-type; Het, heterozygote; Hom, homozygote; n.s., not significant.