TABLE 4.
Variables associated with death-censored graft loss
| Variables | Univariate analyses | Multivariate analyses | ||||
|---|---|---|---|---|---|---|
| HR | P | 95% CI | HR | P | 95% CI | |
| Age >55 at txp | 1.01 | 0.97 | 0.41–2.49 | |||
| Male | 1.17 | 0.68 | 0.53–2.60 | |||
| White | 0.67 | 0.36 | 0.28–1.58 | |||
| History of failed transplant | 0.85 | 0.73 | 0.34–2.12 | |||
| DM as cause of ESRD | 0.51 | 0.27 | 0.15–1.71 | |||
| Living donor transplant | 1.76 | 0.13 | 0.83–3.74 | |||
| Depleting Induction | 1.38 | 0.39 | 0.65–2.94 | |||
| DSA present at biopsy | 1.18 | 0.66 | 0.55–2.55 | |||
| Chronicity score >8 | 11.91 | 0.0001 | 5.38–26.33 | 1.54 | 0.48 | 0.45–5.25 |
| eGFR response, yes/no | 0.03 | 0.001 | 0.004–0.26 | 0.12 | 0.013 | 0.02–0.64 |
| DSA response, yes/no | 0.11 | 0.004 | 0.026–0.49 | 1.28 | 0.78 | 0.21–7.77 |
| UPC response, yes/no | 0.38 | 0.01 | 0.18–0.82 | 1.02 | 0.96 | 0.32–3.20 |
| MVI response, yes/no | 0.65 | 0.55 | 0.15–2.75 | |||
| C4d response, yes/no | 1.61 | 0.45 | 0.42–6.08 | |||
| Change in MVI between two biopsies | 0.86 | 0.2 | 0.69–1.09 | |||
| Rituximab use | 0.13 | 0.0001 | 0.05–0.34 | 0.27 | 0.10 | 0.05–1.29 |
CI, confidence interval; DM, diabetes mellitus; DSA, donor-specific antibody; eGFR, estimated glomerular filtration rate; ESRD, End-Stage Renal Disease; HR, hazard ratio; MVI, microvascular inflammation; txp, transplantation; UPC, urine-protein creatinine ratio.