Table 1. MICs and MICics of B. abortus 2308 pAC042.8.
| Antibiotic | MIC | MICic | Cmax | ||
|---|---|---|---|---|---|
| μg/ml | μg/ml | SE | xMIC | μg/ml | |
| CIP | 0.125–0.19 | 6.73 | 1.12 | 35–54 | 2.2 [81] |
| STR | 1–2 | >400 | - | >200 | 30–40 [82] |
| DOX | 0.125–0.25 | 6.09 | 1.27 | 24–49 | 2 [83] |
| RIF | 0.5–0.75 | 6.57 | 4.45 | 9–13 | 10 [84] |
| DOX + STR |
1.58 3.16 |
- | 6–13 2–3 |
2 [83] 30–40 [82] |
|
| DOX + RIF |
1.64 1.64 |
- | 6–13 2–3 |
2 [83] 10 [84] |
|
MIC = Minimal Inhibitory Concentration determined by E-test, n ≥ 3.
MICic = Minimal Inhibitory Concentration within macrophages extrapolated from the concentration-response curves (Fig 1), n = 3.
SE = standard error of MICic.
xMIC = MICic value expressed as x times the MIC, values rounded.
Cmax = maximum reachable concentrations in human serum based on the indicated references.
CIP = ciprofloxacin, STR = streptomycin, DOX = doxycycline, RIF = rifampicin