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. 2022 Jul 22;10:952015. doi: 10.3389/fcell.2022.952015

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Copyright © 2022 Yuan, Jiang, Qin and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The identification and phylogenetic analysis of invertebrate GSDM. (A) The phylogenetic tree of the major metazoan phyla with GSDM distribution. Orange and black icons indicate GSDM-positive and negative phyla, respectively. (B) The phylogenetic analysis of GSDM in invertebrate and vertebrate. The different categories of GSDM and metazoan clades are presented in different colors. The vertebrate and invertebrate GSDM are shaded with yellow and blue, respectively. (C) A micrograph of Trichoplax adhaerens (phylum: Placozoa). (D) The violin plot showing the Ka/Ks ratios of GSDM_in in Cnidaria and Mollusca. (E) The genetic distance between invertebrate GSDM_in and vertebrate GSDMA/B/C/D/E/F. The color from blue to red indicates decreasing genetic distance.