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. 2022 Jul 22;9:903412. doi: 10.3389/fcvm.2022.903412

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Copyright © 2022 Hu, Zhang, Han, Zhao, Liu and An.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–E) Exploration of differences between HC and T2DM-CHD groups. (A) PCA score scatter plot. (B) OPLS-DA score scatter plot. (C) Random permutation test of the OPLS-DA model. (D) Venn diagram depicting the overlap of different statistical methods. (E) ROC curves of the potential biomarkers for the discrimination of HC and T2DM-CHD groups. (F–J) Exploration of differences between T2DM and T2DM-CHD groups. (F) PCA score scatter plot. (G) OPLS-DA score scatter plot. (H) Random permutation test of the OPLS-DA model. (I) Venn diagram depicting the overlap of different statistical methods. (J) ROC curves of the potential biomarkers for the discrimination of T2DM and T2DM-CHD groups. (K) A forest plot of the significantly changed FFAs between T2DM and T2DM-CHD groups. Red indicates FFAs with P < 0.05 in multivariate analysis.