TABLE 2.
Results of clinical laboratory test.
| Characteristics | HC | T2DM | T2DM-CHD | P1 value (HC vs T2DM) | P2 value (HC vs T2DM-CHD) | P3 value (T2DM vs T2DM-CHD) |
| Blood biochemistry | ||||||
| TC (mmol/L) | 4.56 ± 0.94 | 4.73 ± 1.06 | 3.93 ± 1.07 | 0.134 | 7.58E-07&& | 6.00E-09** |
| HDL-C (mmol/L) | 1.33 ± 0.34 | 1.25 ± 0.40 | 1.09 ± 0.29 | 0.010 | 3.10E-09&& | 0.001** |
| LDL-C (mmol/L) | 2.62 ± 0.72 | 2.82 ± 0.84 | 2.20 ± 0.84 | 0.028 | 1.65E-05&& | 1.06E-08** |
| TG (mmol/L) | 1.32 ± 0.69 | 1.70 ± 1.17 | 1.68 ± 1.20 | 0.005 | 0.025& | 0.618 |
| Glucose (mmol/L) | 5.24 ± 2.17 | 8.50 ± 3.68 | 9.51 ± 4.49 | 1.15E-22 | 9.22E-26&& | 0.111 |
| Uric (μmol/L) | 303 ± 71 | 315 ± 78 | 334 ± 91 | 0.212 | 0.006&& | 0.120 |
| DBIL (μmol/L) | 3.47 ± 1.86 | 3.23 ± 2.32 | 4.03 ± 2.10 | 0.163 | 0.0342& | 7.00E-04** |
| IBIL (μmol/L) | 9.44 ± 4.20 | 10.3 ± 5.80 | 8.74 ± 4.39 | 0.493 | 0.1090 | 0.041* |
| TBA (μmol/L) | 4.44 ± 3.68 | 4.06 ± 3.78 | 4.10 ± 4.28 | 0.262 | 0.1338 | 0.616 |
| Creatinine (μmol/L) | 70.6 ± 16.8 | 70.2 ± 16.5 | 77.7 ± 21.9 | 0.514 | 0.0248& | 0.008** |
| HsCRP (mg/L) | NA | 2.93 ± 3.27 | 4.24 ± 3.82 | 0.001** | ||
| AST (U/L) | 24.1 ± 10.5 | 28.0 ± 71.3 | 69.6 ± 111.8 | 0.006 | 0.057 | 2.10E-04** |
| ALT (U/L) | 21.6 ± 11.1 | 25.4 ± 25.3 | 32.8 ± 35 | 0.579 | 9.09E-05&& | 0.002** |
| CK (U/L) | 98.6 ± 45.1 | 90.7 ± 51.0 | 442 ± 877 | 0.013 | 0.240 | 0.005** |
| MMB (ng/L) | NA | NA | 32.7 ± 74.3 | |||
| CTNI (ng/L) | NA | NA | 16.3 ± 37.3 | |||
| LDH (U/L) | 172 ± 29 | 158 ± 40 | 282 ± 258 | 2.88E-05 | 0.005&& | 3.08E-08** |
| HBDH (U/L) | 140 ± 23 | 134 ± 27 | 252 ± 252 | 0.030 | 1.37E-04&& | 3.93E-07** |
| ALP (U/L) | 82.7 ± 23.7 | 91.5 ± 25.1 | 86.6 ± 26.5 | 7.06E-04 | 0.143 | 0.067 |
| GGT (U/L) | 30.1 ± 26.2 | 40.2 ± 52.0 | 36.8 ± 31.4 | 0.083 | 0.007&& | 0.582 |
| HCY (μmol/L) | NA | 13.5 ± 4.8 | 16.9 ± 6.3 | 1.57E-07** | ||
| NT-proBNP (pg/mL) | NA | NA | 1,146 ± 2,098 | |||
| HbA1c (%) | NA | 9.85 ± 2.23 | 8 ± 1.61 | 3.55E-10** | ||
| Blood pressure | ||||||
| SBP (mmHg) | 128 ± 16 | 146 ± 26 | 158 ± 30 | 1.97E-10 | 9.00E-18&& | 2.56E-04** |
| DBP (mmHg) | 78.4 ± 10.9 | 83.9 ± 15.3 | 90.7 ± 20.1 | 3.52E-04 | 1.96E-08&& | 0.006** |
| Erythrocyte function | ||||||
| RBC (× 1012/L) | 4.58 ± 0.47 | 4.47 ± 0.48 | 4.36 ± 0.54 | 0.094 | 0.001&& | 0.071 |
| HGB (g/L) | 142 ± 13 | 138 ± 16 | 140 ± 92 | 0.018 | 7.26E-06&& | 0.030* |
| HCT (%) | 41.4 ± 3.5 | 39.6 ± 4.2 | 38.6 ± 4.6 | 2.38E-04 | 1.16E-07&& | 0.068 |
| MCV (fl) | 90.7 ± 4.6 | 88.8 ± 5.2 | 88.7 ± 4.8 | 4.05E-04 | 0.002&& | 0.773 |
| MCH (pg) | 31.1 ± 2.1 | 30.8 ± 2.2 | 30.3 ± 2.1 | 0.443 | 0.015& | 0.077 |
| MCHC (g/L) | 343 ± 11 | 346 ± 12 | 343 ± 12 | 0.003 | 0.990 | 0.005** |
| RDW-CV (%) | 12.9 ± 0.9 | 12.8 ± 1.0 | 13.1 ± 1.3 | 0.090 | 0.036& | 3.56E-04** |
| Blood platelet | ||||||
| PLT (× 109/L) | 213 ± 56 | 219 ± 53 | 207 ± 49 | 0.239 | 0.483 | 0.043* |
| PDW (fl) | 12.6 ± 2.2 | 12.6 ± 1.8 | 12.4 ± 1.7 | 0.494 | 0.833 | 0.352 |
| MPV (fl) | 10.5 ± 1 | 10.5 ± 0.9 | 10.6 ± 0.9 | 0.605 | 0.197 | 0.371 |
| P-LCR (%) | 28.8 ± 8.2 | 29.1 ± 7.1 | 29.6 ± 7.1 | 0.534 | 0.254 | 0.547 |
| Coagulation function | ||||||
| PT (s) | 11.3 ± 0.8 | 11.2 ± 0.8 | 11.5 ± 1.9 | 0.094 | 0.837 | 0.228 |
| PA (%) | 93.7 ± 6.3 | 97.8 ± 8 | 93.9 ± 10.6 | 4.03E-06 | 0.707 | 4.36E-04** |
| PR | 1.00 ± 0.06 | 0.98 ± 0.07 | 1.01 ± 0.15 | 0.001 | 0.461 | 0.028* |
| INR | 0.99 ± 0.05 | 0.96 ± 0.06 | 0.99 ± 0.16 | 1.45E-05 | 0.573 | 0.001** |
| APTT (s) | 28.6 ± 3.5 | 27.6 ± 3.9 | 28.8 ± 5.6 | 0.020 | 0.457 | 0.247 |
| FBG (mg/dL) | 263 ± 51 | 292 ± 72 | 296 ± 75 | 1.82E-04 | 9.47E-05&& | 0.712 |
| TT (s) | 19.1 ± 1.5 | 18.7 ± 1.7 | 20.0 ± 9.3 | 0.004 | 0.354 | 0.094 |
| D-DIMER (mg/L) | NA | 0.36 ± 0.50 | 0.42 ± 0.57 | 0.016* | ||
| Thyroid Function | ||||||
| FT3 (pg/mL) | NA | 2.61 ± 0.43 | 2.58 ± 0.75 | 0.124 | ||
| FT4 (ng/dl) | NA | 1.05 ± 0.14 | 1.06 ± 0.17 | 0.571 | ||
| STSH (uIU/ml) | NA | 1.91 ± 1.97 | 1.66 ± 1.62 | 0.079 |
Data was presented as mean ± SD, unless otherwise specified. P values were calculated by hypothesis testing. Data distribution was assessed by the Shapiro–Wilk test. Bilateral student’s t-test was used for normally distributed data. While the Mann–Whitney U test was used for non-parametric data. (&, *), P < 0.05; (&&, **), P < 0.01.