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. 2022 Jul 22;13:924747. doi: 10.3389/fphar.2022.924747

TABLE 7.

Results of pairwise meta-analyses for extracranial hemorrhage.

Comparative medication Reference medication Number of studies Pairwise meta-analyses
Number of control Number of patients MD/OR/RR 95% CI I2 P
Heparin Placebo 9 288 330 0.71 [0.25, 2.05] 32 0.22
Safflower yellow Placebo 7 368 394 NA NA 0 0.93
Stent retrievers Placebo 5 652 634 1.08 [0.64, 2.30] 0 0.63
Ginkgo biloba Placebo 12 266 281 0.82 [0.43, 1.57] 0 0.443
Tirofiban Placebo 6 216 213 1.14 [0.72, 1.82] 0 0.57
Edaravone plus rt-PA Placebo 8 221 221 0.44 [0.29, 0.66] 0 0.93
Alpha 1 Placebo 6 467 595 1.25 [0.97, 1.62] 9 0.09
TNK Placebo 4 658 676 1.07 [0.6, 1.93] 0 0.81
MTE plus stent retrievers Placebo 5 146 144 0.59 [0.35,0.97] 0 0.83
MTE Placebo 5 141 140 3.05 [0.44, 21.23] 0 0.25
tPA plus MTE Placebo 7 2639 2640 0.93 [0.72, 1.19] 29 0.13
Cilostazol Placebo 6 1728 1731 0.29 [0.15, 0.56] 0 0.77

CI, confidence interval; MD, mean difference; OR, risk ratio; I2, heterogeneity, TNK, tenecteplase.