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. 2022 Jul 21;11:e78277. doi: 10.7554/eLife.78277

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© 2022, Matsuo, Yuan, Kim et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 6. — (a) Scheme of ICI treatment. Foxa2^f/fLtf^Cre+ and Foxa2^f/fPgr^Cre+ mice were treated with leukemia inhibitory factor (LIF) (20 μg) on day 8. Pregnancy was evaluated on day 10, 2 days after LIF administration. (b) Representative photographs of uteri in Foxa2^f/fLtf^Cre+ and Foxa2^f/fPgr^Cre+ mice with ICI treatment 2 days after LIF administration. Foxa2^f/f mice have normal day 10 implantation sites, suggesting implantation occurs under 25 μg ICI treatment in Foxa2^f/f mice. Scale bar: 10 mm. Histological pictures of implantation sites in panel b were presented in panel c. Scale bar: 500 μm. (d) Average number of implantation sites in Foxa2^f/fLtf^Cre+ and Foxa2^f/fPgr^Cre+ mice with ICI treatment. Numbers and percentage on bars indicate mice with implantation sites over total number of mated mice. (e) Litter sizes of Foxa2^f/fLtf^Cre+ and Foxa2^f/fPgr^Cre+mice with ICI treatment. Numbers and percentage on bars indicate mice with pups over total number of mated mice.