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. 2022 Jun 23;28(14):3076–3090. doi: 10.1158/1078-0432.CCR-22-0486

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 2. Measurement of pO2 in mouse tissues. A, Oxygen tension map in the normal murine skin of a mouse breathing air (21% oxygen). The depth projection of vasculature (black lines) is overlaid. B, Scatter plot of interstitial oxygen tension [mmHg] versus the diameter of the nearest vessel [μm] in mice breathing air. C, Oxygen tension depth projection map in the normal murine skin of a mouse breathing 100% oxygen. D, Scatter plot of interstitial oxygen tension versus the diameter of the nearest vessel in mice breathing 100% oxygen. The detection limit of 122 mmHg is apparent in the data. E, Table of Pearson correlation coefficients and the P value of the correlation of oxygen tension and nearest vessel diameter. F, Scatter plot of measured oxygen tension versus the distance to the nearest vessel in the skin of mice breathing 21% oxygen. G, Scatter plot of measured oxygen tension versus the distance to the nearest vessel in the skin of mice breathing 100% oxygen. The detection limit of 122 mmHg is apparent in the data. H, Table of Pearson correlation coefficients, and the P value of the correlation of oxygen tension and distance to the nearest vessel. — Measurement of pO₂ in mouse tissues. A, Oxygen tension map in the normal murine skin of a mouse breathing air (21% oxygen). The depth projection of vasculature (black lines) is overlaid. B, Scatter plot of interstitial oxygen tension [mm Hg] versus the diameter of the nearest vessel (μm) in mice breathing air. C, Oxygen tension depth projection map in the normal murine skin of a mouse breathing 100% oxygen. D, Scatter plot of interstitial oxygen tension versus the diameter of the nearest vessel in mice breathing 100% oxygen. The detection limit of 122 mm Hg is apparent in the data. E, Table of Pearson correlation coefficients and the P value of the correlation of oxygen tension and nearest vessel diameter. F, Scatter plot of measured oxygen tension versus the distance to the nearest vessel in the skin of mice breathing 21% oxygen. G, Scatter plot of measured oxygen tension versus the distance to the nearest vessel in the skin of mice breathing 100% oxygen. The detection limit of 122 mm Hg is apparent in the data. H, Table of Pearson correlation coefficients, and the P value of the correlation of oxygen tension and distance to the nearest vessel.