Table 1.
Twenty-four hour pharmacokinetic analysis of hemp derived cannabinoids (CBD, CBDA, THC, THCA, CBG and CBGA).
| Dose (mg/kg) | Cmax (ng/mL) | Tmax (h) | T1/2 el (h) | AUC 0—t (ng/mL) | MRT (h) | Css Ave (ng/mL)c | |
|---|---|---|---|---|---|---|---|
| CBD | 1.37 ± 0.15 | 282.0 ± 149.4 | 2 ± 0 | 2.1 ± 1.1 | 908.5 ± 528.1 | 3.8 ± 1.0 | 102.1 ± 46.3 |
| CBDA | 1.13 ± 0.12 | 1,011.3 ± 495.4 | 1.6 ± 1.1 | 2.7 ± 1.4 | 2,638.7 ± 1,284.8 | 3.3 ±1.1 | 204.5 ± 87.8 |
| THCa | 0.05 ± 0.01 | 40.9 ± 12.9 | 2 ± 0 | 1.6 ± 0.4 | 156.5 ± 65.8 | 3.7 ± 0.4 | 11.9 ± 5.2 |
| THCA | 0.03 ± 0.003 | 87.9 ± 34.0 | 2 ± 0.9 | 3.8 ± 1.3 | 434.0 ± 229.1 | 5.5 + 2.1 | 43.3 ± 13.9 |
| CBGb | 0.03 ± 0.003 | 4.35 ± 1.0 | 2 ± 0 | 0.9 ± 0.1 | 11.4 ± 2.8 | 2.3 ± 0.1 | 2.3 ± 0.5 |
| CBGA | 0.03 ± 0.003 | 19.7 ± 5.5 | 1 ± 0.2 | 0.7 ± 0.1 | 34.1 ± 9.5 | 1.5 ± 0.2 | 4.8 ± 1.3 |
aRepresents 7 of 8 cats due to lack of time points having absorption above the lower level of detection to perform pharmacokinetic analysis in 1 cat. bRepresents 6 or 8 cats due to the lack of time points having adequate absorption above the lower level of detection to perform pharmacokinetic analysis in 2 cats. cCss Ave = predicted steady state serum concentrations after 5 half-lives of twice daily dosing.