Table 4.
Comparison of Serum pharmacokinetic of single oral dosing CBD oil in previous studies.
| References | Dosage of CBD (mg/kg) | Carrier of CBD | Fasted or not | Cmax (ng/mL) | Tmax (h) | T (h) | AUC (ng-h/mL) | MRT (h) |
|---|---|---|---|---|---|---|---|---|
| Cats | ||||||||
| Deabold et al.a | 1 | Fish oil | Fasted | 43 ± 9 | 2.0 ± 0.6 | 1.5 ± 0.1 | 164 ± 29 | 3.5 ± 1.4 |
| Dogs | ||||||||
| Bartner et al. (30)d | 5.77j | CBD- infused oil | Fasted | 625.3 ± 164.3 | NAh | 199.7 ± 55.9 | 135.6 ± 46.3 | 217 ± 46 |
| Micro- encapsulated | 346.3 ± 158.7 | 95.4 ± 29.2 | 98.0 ± 43.3 | 353 ± 48 | ||||
| CBD-infused transdermal cream | 74.3 ± 127.2 | NDi | 11.7 ± 18.9 | 490 ± 74 | ||||
| 11.54j | CBD-infused oil | Fasted | 845.5 ± 262.2 | NAh | 127.5 ± 32.2 | 297.6 ± 112.8 | 298 ± 43 | |
| Micro- encapsulated | 578.1 ± 287.1 | 115.9 ± 88.6 | 162.8 ± 61.2 | 332 ± 73 | ||||
| CBD-infused transdermal cream | 277.6 ± 476 | NDi | 29.7 ± 29.6 | 464 ± 123 | ||||
| Gamble et al.b | 1 | Fish oil | Fasted | 102 (61–132) | 1.5 (1.0–2.0) | 4.2 (3.8–6.8) | 367 (183–437) | 5.6 (4.2–9.1) |
| 4 | Fish oil | Fasted | 591 (389–905) | 2.0 (1.0–2.0) | 4.2 (3.8–4.8) | 2,658 (1,753–3,048) | 5.6 (5.1–7.0) | |
| Deabold et al.a | 1 | Soft chews | Fasted | 301 ± 63 | 1.4 ± 0.2 | 1.0 ± 0.2 | 1,297 ± 210 | 1.4 ± 0.3 |
| Chicoine et al.d | 2 | CHEc | Fasted | 213 (49) | 2.1 (1.0) | 2.5 (0.5)e | 759 (335)f | 346 (146) |
| 5 | CHEc | Fasted | 838 (304) | 1.9 (0.6) | 2.6 (0.4)e | 2,935 (1,244)f | 487 (182) | |
| 10 | CHEc | Fasted | 1,868 (698) | 2.3 (0.5) | 2.3 (0.2)e | 7,239 (2,393)f | 588 (218) | |
| Wakshlag et al. | 1 | MCT & sesame oil | Fed | 145 ± 69 | 1.5 ± 0.5 | 4.1 ± 0.7 | 635 ± 399 | 5.2 ± 1.4 |
| 1 | Sunflower lecithin & sesame oil | 124 ± 62 | 2.0 ± 1.1 | 4.4 ± 1.4 | 683 ± 146 | 6.5 ± 2.1 | ||
| 1 | Soft chews | 226 ± 89 | 2.5 ± 1.2 | 3.8 ± 0.3 | 826 ± 74 | 5.3 ± 1.4 | ||
| Human | ||||||||
| Silmore et al. (23)g | 2.5 | Sesame oil | Fasted | 58.55 (60.52) | 4.27 (23.25) | NAh | 236.21 (46.05) | NAh |
| Fed | 218.51 (36.37) | 3.28 (34.64) | 1,015.45 (63.54) | |||||
Cmax, maximum concentration; Tmax, time of maximum concentration; T1/2, half-life of elimination; AUC 0-t, area under the curve (time 0–24 h); MRT, median residence time. aMean ± standard error (SE) in parameters; bMedian and range in parameters; cCannabis-derived herbal extracts; dMean ± Standard deviation (SD) in parameters; eT 1/2 phase, from 4 to 12 h post-dose; fDose-Adjusted AUC from 0 to 12 h (ng *h/mL per mg/kg); gThe mean Cmax, Tmax, AUC 0-∞, and all corresponding standard deviations and coefficient of variation (CV%); hNot available; iNot determined; jCalculated with average BW.