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. 2022 Jul 22;9:887062. doi: 10.3389/fmed.2022.887062

Table 1.

The hierarchical clustering was drawn by using the top 100 genes.

P6con2 P6con1 P6con3 P6sev3 P6sev2 P6sev1 P30con3 P30sev1 P30sev2 P30sev3 P30con1 P30con2
ENSMUSG00000099227 Mir8114 0.339139 0.639115 0.773078 0.813188 0.727697 1.057615 8.513753 8.709748 8.764851 0.809721 0.52445 0.516952
ENSMUSG00000089739 Gm20431 0 0 0 0 0 0 0 5.512488 0 0 0 0
ENSMUSG00000102543 Pcdhgc5 1.540981 2.474268 2.981063 2.53654 5.313874 1.821173 3.22469 5.200865 5.106705 3.613448 5.326615 3.009621
ENSMUSG00000058488 Kl 0.643611 0.679354 0.855867 0.404465 1.337473 1.608458 1.81228 4.231118 3.980575 3.774451 3.603163 4.577633
ENSMUSG00000022425 Enpp2 2.596566 2.69461 3.155094 2.854968 5.003974 5.329215 4.483309 8.162468 7.870834 7.761079 7.505069 8.720711
ENSMUSG00000026051 1500015O10Rik 2.320001 2.721176 2.426835 2.669784 4.739422 5.290961 1.488714 5.427677 5.423005 5.423128 5.275562 6.368469
ENSMUSG00000004655 Aqp1 0.557267 0.602999 0.603644 0.691891 3.472448 3.937689 0.281892 3.454538 3.451919 3.13121 2.872202 3.648984
ENSMUSG00000061808 Ttr 0.60029 2.088285 2.793013 1.957387 10.64071 11.09667 4.813186 11.57848 11.44686 11.29509 11.24899 12.17576
ENSMUSG00000079436 Kcnj13 0.052239 0.281671 0.603794 0.085789 2.065224 2.645705 0.252962 4.297776 4.290035 4.059775 3.860188 4.782417
ENSMUSG00000034739 Mfrp 0.037954 0.082597 0.083571 0.097811 1.396841 1.97803 0.280518 3.235523 3.351814 2.84732 2.670659 3.463689
ENSMUSG00000037086 Prr32 0 0 0.170719 0 2.314767 2.530235 0.178631 2.985613 3.039295 2.870868 2.745784 3.324548
ENSMUSG00000039672 Kcne2 0 0 0 0.062171 2.761808 3.117162 0.185855 3.768732 3.251112 3.404531 3.285776 4.341999
ENSMUSG00000022949 Clic6 0.207005 0.348554 0.365233 0.282579 3.168213 3.282571 0.880122 4.438601 4.341677 4.100857 3.937147 4.816006
ENSMUSG00000115625 2900040C04Rik 0 0 0 0 2.433959 2.891823 0.436016 3.821567 3.692222 3.721285 3.621763 4.458132
ENSMUSG00000046093 Hpcal4 2.890394 4.03528 3.389683 2.743864 3.534995 3.096736 5.357839 7.632003 5.30247 7.505601 4.420493 5.321748
ENSMUSG00000022602 Arc 2.186194 2.283747 2.383563 2.002078 2.484504 2.487388 5.042014 6.054658 6.572029 6.428091 4.782327 4.650254
ENSMUSG00000030701 Plekhb1 2.762791 2.762292 2.826443 2.754226 2.562928 2.613716 5.580811 4.832645 6.071605 5.212776 5.109616 5.308182
ENSMUSG00000032854 Ugt8a 1.048664 0.952906 1.271944 1.073586 1.162132 1.302902 4.123735 3.504565 4.221014 4.145976 4.533896 4.726676
ENSMUSG00000043448 Gjc2 0.389721 0.165084 0.372247 0.186042 0.550101 0.368633 3.587328 2.714377 3.472717 3.551479 4.007932 3.977796
ENSMUSG00000006782 Cnp 3.912011 3.800569 3.899937 3.656499 3.807092 4.141042 6.805457 6.017177 7.072083 7.001268 7.230329 7.253384
ENSMUSG00000032554 Trf 2.318652 2.225575 2.678687 2.283432 2.362017 2.655249 5.853685 5.619558 6.399286 6.210752 6.295796 6.435897
ENSMUSG00000050121 Opalin 0 0 0.053712 0.117255 0 0 4.041932 3.248058 4.427679 4.237906 4.389326 4.329293
ENSMUSG00000036634 Mag 0.438031 0.390555 0.38147 0.407697 0.495347 0.712602 5.21762 4.539451 5.638096 5.626706 5.746751 5.734548
ENSMUSG00000026830 Ermn 0.209977 0.280025 0.297944 0.316506 0.32334 0.267793 3.709827 3.456199 4.314028 4.307012 4.261882 4.471121
ENSMUSG00000037625 Cldn11 1.717406 2.168798 2.296076 1.855062 2.343677 2.043547 6.850832 6.071192 7.208068 7.131991 7.27962 7.363363
ENSMUSG00000027375 Mal 0.468541 1.056645 1.177564 0.696692 1.061306 1.060291 6.881021 6.121725 7.208538 7.161206 7.252946 7.406027
ENSMUSG00000031425 Plp1 1.184008 1.381746 1.535831 1.082337 1.55125 1.689505 8.046047 7.371442 8.510116 8.353888 8.502598 8.780668
ENSMUSG00000032517 Mobp 0.176754 0.126103 0.071435 0.032413 0.078641 0.091435 7.079269 6.60952 7.701476 7.530721 7.393925 7.725572
ENSMUSG00000041607 Mbp 2.900006 2.975117 2.868769 2.486042 2.879045 2.897536 7.021765 6.755859 7.578742 7.369391 7.204559 7.468361
ENSMUSG00000033579 Fa2h 0.721697 0.523699 0.760457 0.467907 0.371569 0.713993 4.426835 3.586859 4.512877 4.342097 4.368211 4.870577
ENSMUSG00000076439 Mog 0.949917 0.757949 1.010251 0.798649 0.592399 0.676379 5.655879 4.790305 5.873042 5.837576 6.13841 6.235318
ENSMUSG00000073680 Tmem88b 0.66543 0.483404 0.364741 0.317987 0.232424 0.106453 4.127202 3.527263 4.328289 4.472316 4.378304 4.617043
ENSMUSG00000037166 Ppp1r14a 0.655845 0.84407 0.647737 0.826795 0.506365 0.534378 3.589188 2.91349 3.879721 3.621852 3.772591 4.005399
ENSMUSG00000056966 Gjc3 0.424219 0.551056 0.374767 0.340942 0.41214 0.552782 3.297991 2.727668 3.688249 3.565231 3.377548 3.765232
ENSMUSG00000026879 Gsn 2.225278 2.557166 2.65014 2.231915 2.991605 3.126786 5.20788 4.665979 5.450108 5.332465 5.677892 5.814907
ENSMUSG00000036907 C1ql2 1.603376 1.535475 2.055736 2.262293 2.178253 2.094157 5.313709 5.180862 5.075851 5.107971 5.130215 4.856868
ENSMUSG00000107272 Gm34583 0 0 0.194649 0 0.335162 0 3.297843 2.669013 3.473341 3.491618 3.013496 3.170002
ENSMUSG00000049892 Rasd1 1.415436 1.851232 1.804416 1.537303 1.824477 1.67218 4.95257 4.430186 4.950103 4.796765 4.6052 4.392877
ENSMUSG00000005716 Pvalb 0.40242 0.37835 0.260647 0.200058 0.285336 0.687405 4.486644 4.438122 4.477046 4.589179 4.680512 4.279853
ENSMUSG00000007594 Hapln4 0.67364 0.768904 0.771197 0.680055 0.711176 0.786114 5.114192 4.949516 4.952833 4.841899 4.878249 4.671705
ENSMUSG00000074968 Ano3 0.877627 0.891124 1.00526 0.744247 0.639223 1.028931 3.937192 3.916454 4.035102 3.854804 3.722682 3.8312
ENSMUSG00000024883 Rin1 1.182804 1.628938 1.53163 1.128684 1.384394 1.225824 4.191679 4.176614 4.029093 4.186772 3.992423 4.046182
ENSMUSG00000017167 Cntnap1 1.859463 2.379732 2.362483 1.866618 2.015137 2.401964 5.294768 5.342973 5.29708 5.226029 5.1251 5.06464
ENSMUSG00000085838 Chn1os1 4.463286 4.940295 5.015282 4.336657 4.744263 5.035754 8.203587 8.017724 7.764591 7.755341 7.726485 7.657788
ENSMUSG00000064353 mt-Td 1.419549 1.652578 1.841132 1.28329 1.704404 1.592377 4.271732 4.43539 4.680096 4.258663 3.934356 4.333975
ENSMUSG00000021750 Fam107a 3.323282 3.500449 3.761516 3.131521 3.763401 3.752174 6.484659 6.747674 6.748346 6.655248 6.354992 6.557933
ENSMUSG00000104797 Mir1897 0.018215 3.752156 2.296082 0.092475 0.0276 3.072096 3.894131 0.048836 3.089385 0.309142 0.002138 4.190689
ENSMUSG00000038155 Gstp2 0 2.78686 2.176886 0 0 2.740684 0 2.687933 2.884693 3.460866 0 1.195596
ENSMUSG00000065968 Ifitm7 0.034546 3.406845 3.418375 3.253375 0.119296 3.299889 2.968475 3.059169 2.983583 2.949681 2.724876 0.056279
ENSMUSG00000098265 Gm27517 0.372889 0.41968 0.327247 0.147016 5.229758 0.405011 4.488657 0.138088 0.052523 0.038445 0.402865 4.467028
ENSMUSG00000116048 2-Sep 1.647756 1.375676 4.653767 2.182891 4.639728 1.420056 3.911606 1.504378 0 3.988841 3.687734 4.172691
ENSMUSG00000087563 Gm14205 0 0 4.722188 0 0 0 0 0 0.013082 0 4.450827 0
ENSMUSG00000029168 Dpysl5 5.956252 5.933384 5.961096 5.957929 5.76294 5.962918 2.675896 2.99459 2.806494 3.073291 2.835077 2.980861
ENSMUSG00000047139 Cd24a 7.412661 7.164381 7.280045 7.544802 7.230405 7.235592 2.784359 3.135097 2.85593 3.070662 3.025006 3.284487
ENSMUSG00000022865 Cxadr 6.127147 6.181832 6.293292 6.225999 6.057464 6.149617 2.010012 1.966 2.045834 1.846655 1.863141 2.140173
ENSMUSG00000024501 Dpysl3 8.574621 8.591108 8.61324 8.653219 8.459495 8.583664 3.610343 3.751818 3.460116 3.649018 3.610066 3.734979
ENSMUSG00000036913 Trim67 5.305222 5.265061 5.265873 5.503747 5.146142 5.36841 0.877609 1.021301 1.14274 1.138241 1.072901 0.960284
ENSMUSG00000031285 Dcx 5.27977 5.219535 5.420898 5.483797 5.111164 5.345898 1.24005 1.328293 1.332337 1.354823 1.26626 1.366695
ENSMUSG00000025789 St8sia2 5.12088 5.009673 4.795467 5.205127 4.839677 4.733361 0.903026 0.888194 0.743614 0.801173 0.749059 0.846253
ENSMUSG00000042834 Nrep 8.730464 8.694268 8.510802 8.686963 8.480076 8.464634 4.493812 4.585504 4.589183 4.485819 4.538477 4.622351
ENSMUSG00000074480 Mex3a 3.615988 3.591072 3.571556 3.834256 3.452504 3.630161 0.938506 0.745443 0.968905 0.937242 0.86646 0.920821
ENSMUSG00000041642 Kif21b 5.492827 5.688199 5.635442 5.587384 5.451578 5.637688 2.645654 2.879272 2.71721 2.750449 2.607779 2.650084
ENSMUSG00000018012 Rac3 7.198696 6.963205 6.959161 7.074956 6.980815 6.90353 3.436679 3.661962 3.165043 3.42661 3.678316 3.36163
ENSMUSG00000047261 Gap43 9.281286 9.18918 9.199478 9.367284 9.213413 9.134252 6.528261 6.702916 6.29199 6.559983 6.649484 6.631088
ENSMUSG00000079523 Tmsb10 9.056489 8.834222 8.712459 8.807929 8.646697 8.56338 5.896677 5.940514 5.900179 6.119379 5.94729 5.958088
ENSMUSG00000037568 Vash2 3.476223 3.339786 3.230416 3.698707 3.432289 3.426754 0.847694 0.437191 0.642145 0.773907 0.659888 0.59595
ENSMUSG00000029005 Draxin 4.08241 3.857957 3.931712 4.17607 3.686309 3.95187 0.735826 0.642166 0.559072 0.487562 0.767514 0.658067
ENSMUSG00000031628 Casp3 5.31873 5.108197 5.123518 5.401578 5.048968 5.114293 2.157852 1.817973 2.008147 1.725975 2.058693 2.044331
ENSMUSG00000045136 Tubb2b 10.4977 10.4071 10.33577 10.52977 10.35218 10.41949 7.463822 7.04191 7.20682 7.274981 7.438784 7.212073
ENSMUSG00000029121 Crmp1 7.923535 7.852199 7.930473 7.994561 7.865559 7.927148 5.371702 5.08746 5.135819 5.075436 5.279559 5.055205
ENSMUSG00000047945 Marcksl1 9.473849 9.287881 9.230921 9.410577 9.272566 9.152915 6.502186 6.328559 6.409094 6.34537 6.691804 6.343286
ENSMUSG00000072235 Tuba1a 11.72084 11.63042 11.56435 11.76712 11.66514 11.58274 9.002722 8.816189 8.893305 8.972796 9.165928 8.910132
ENSMUSG00000044847 Lsm11 5.691031 5.901785 6.011299 5.744274 5.816376 5.985011 3.362233 3.115294 3.137247 3.112455 3.209757 3.112524
ENSMUSG00000096255 Dynlt1b 6.363808 6.243093 6.292348 6.132596 6.285557 6.267778 3.589882 3.20411 3.475759 3.598 3.791634 3.693685
ENSMUSG00000070527 Mkrn3 3.423404 3.235095 3.412129 3.313038 3.186531 3.371228 0.583462 0.436844 0.605046 0.77883 0.943553 0.537681
ENSMUSG00000035551 Igfbpl1 5.095995 4.890607 5.16656 5.284854 4.86535 5.277536 2.261028 1.716814 2.052984 1.709055 2.045768 2.293702
ENSMUSG00000028364 Tnc 4.211886 4.160709 4.343726 4.271429 3.806884 4.173232 1.254142 0.92249 1.181049 1.078118 1.270066 1.309538
ENSMUSG00000041362 Shtn1 5.782274 5.769358 5.777735 6.005109 5.703314 5.74011 2.716395 2.685376 2.927242 2.958568 3.112713 3.365067
ENSMUSG00000044338 Aplnr 3.048 3.168751 3.402846 3.253904 3.163615 3.067377 0.186222 0.129845 0.034183 0.244871 0.634228 0.474575
ENSMUSG00000084728 Mir1905 4.404927 4.201791 4.298829 4.622215 4.106126 4.476413 1.021752 0.877809 1.598562 0.804981 0.739724 1.117915
ENSMUSG00000019874 Fabp7 8.114886 7.887725 8.028364 8.086709 7.677698 7.902722 2.969595 3.79241 4.145775 4.024288 3.590086 3.681293
ENSMUSG00000019890 Nts 5.880063 5.780624 5.638106 6.00656 5.568164 5.497426 2.142706 2.470744 2.514862 3.018826 1.896446 2.262631
ENSMUSG00000095677 Dynlt1f 4.64278 4.261188 4.603206 4.666007 4.444555 4.49313 1.724146 1.497589 1.25608 1.90696 2.31641 1.813998
ENSMUSG00000092074 Dynlt1a 5.376143 5.163592 5.238181 5.043642 5.111786 5.194224 1.448215 1.250842 1.768933 1.357393 2.418522 1.98848
ENSMUSG00000094392 Gm3788 5.263658 4.863463 4.979568 4.841488 5.130374 4.362327 2.286998 2.711215 1.513535 2.18349 2.057185 1.918746
ENSMUSG00000098816 Gm27786 1.807631 3.763076 3.408871 3.15314 3.441816 3.592642 0.202129 0.501566 0.409775 0 0.066467 0.416267
ENSMUSG00000105211 Gm47302 1.789459 3.449842 4.341674 3.166937 3.418886 3.164747 1.347937 0.084804 1.236344 0.078889 0.766359 1.299217
ENSMUSG00000018411 Mapt 7.965571 5.914616 6.009106 5.931301 7.81837 6.0846 4.028522 4.32592 4.196329 5.332961 3.980954 3.902854
ENSMUSG00000023036 Pcdhgc4 3.034378 3.043546 4.998936 6.340767 4.823971 5.837487 4.161959 3.113443 1.636678 1.571729 1.784668 4.086564
ENSMUSG00000102440 Pcdhga9 6.346165 1.824466 1.422592 2.573931 3.442794 1.399153 1.289931 1.057458 1.66033 1.310436 0.989857 2.32774
ENSMUSG00000103585 Pcdhgb4 1.621667 5.718772 5.144098 1.272979 1.102232 1.479735 1.488937 1.116522 1.125121 1.002364 0.89602 1.395783
ENSMUSG00000107062 Gm43580 5.96794 6.198963 6.144148 0.830114 6.015596 0.888223 0.82182 3.483245 3.548295 1.179724 3.112714 0.58281
ENSMUSG00000064365 mt-Ts2 4.450724 4.758022 4.913534 4.260566 4.439895 4.368212 0.475656 5.413932 4.944624 0.650229 0.502835 5.304682
ENSMUSG00000064220 Hist2h2aa1 3.137326 3.920005 3.755308 3.545681 3.681322 3.984228 0 4.947828 0 0 4.59402 4.83802
ENSMUSG00000029711 Epo 3.064989 3.084778 3.132658 0 2.949304 4.204238 2.367764 2.111797 2.973611 0 2.110641 0
ENSMUSG00000037872 Ackr1 4.631 4.55237 4.666553 4.50068 1.406237 4.428772 4.394807 4.31447 4.217929 1.424665 1.460045 2.504411
ENSMUSG00000104953 Gm47308 0.303113 0.308929 0.255961 6.125226 0.287037 6.212159 0.284458 0.321265 0.32725 5.011327 0.282934 0.304265
ENSMUSG00000086503 Xist 0.061271 3.897009 0.016739 4.193859 0.024478 0.022217 0.016205 0.00701 0.03209 0.118198 0.015815 0.030168
ENSMUSG00000098743 Gm27927 0 4.327691 0 4.652368 0 0 0 0 0 0.079767 0 0
ENSMUSG00000074506 Gm10705 4.214571 5.220398 1.965333 4.615738 3.408148 3.801138 1.589732 1.159605 3.044287 5.324437 4.672381 3.056219