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. 2022 Jul 22;13:937466. doi: 10.3389/fmicb.2022.937466

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Copyright © 2022 Garcia-Moreno, Jordan, Günther, Dau, Fritzsch, Vermes, Schoppa, Ignatius, Wildemann, Werz, Löffler and Tuchscherr.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of TLR2 does not affect bacterial persistence. (A,B) Osteoblasts (A) and osteocytes (B) were treated with 50 μM MMG-11 or not and infected with S. aureus LS1. Intracellular bacteria were quantified after 24 h post infection. (C,D) LL-37 was measured after 24 post infection from the supernatants from treated and non-treated osteoblasts (C) and osteocytes (D). Statistical analysis was performed using unpaired t-test. The bars and whiskers represent the means ±SD of different independent experiments n = 3.