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. 2022 Jul 22;13:907331. doi: 10.3389/fgene.2022.907331

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Copyright © 2022 Wang, Pan, Lin, Yuan, Tao and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Establishment of ferroptosis-related hub gene signature in the TCGA set. (A) LASSO coefficient profiles of the expression of 41 candidate genes. (B) Selection of the penalty parameter (λ) in the LASSO model via 10-fold cross-validation. An optimal log λ value is indicated by the vertical black line in the plot. Risk score distribution (C), PCA plot (D), overall survival (OS) status (E), and t-SNE (F) analysis of TCGA cohort. (G) Kaplan–Meier curves for comparison of the OS between low- and high-risk groups. (H) Receiver operating characteristic (ROC) curves verified the prognostic performance of the risk score.