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. 2022 Jul 22;13:943321. doi: 10.3389/fimmu.2022.943321

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Copyright © 2022 Cui, Zhao, Amevor, Du, Wang, Li, Shu, Tian and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms of quercetin on Depression. Quercetin act as an antidepressant by targeting SIRT1 to reverse depressive and anxiety-like behaviors and hippocampal neuroinflammation. The FoxG1/CREB/BDNF/Trkβ-catenin axis clarifies these mechanisms. FOXG1, Forkhead box transcription factor G1; CREB, cAMP response element binding protein; TrKβ, tyrosine receptor kinase A. SOD, superoxide dismutase; CAT, catalase; GSH-Px, glutathione peroxidase; TNF, tumor necrosis factor; IL-1β, interleukin-1 β; MDA, malondialdehyde; and BDNF, brain-derived neurotrophic factor.