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. 2022 Jul 22;13:692437. doi: 10.3389/fphar.2022.692437

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Copyright © 2022 Nakamura, Murasato, Øverby, Kodama, Michimae, Sasaki, Flahou, Haesebrouck, Murayama, Takahashi, Uchida, Suzuki and Matsui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of acid suppressants on the NHPH number by PCR. PCR analysis showed significant difference between infection alone and administered agents (F = 5.33 and p = 0.008 by one-way ANOVA). Post hoc analyses (Bonferroni correction) revealed that the infection-alone group is significantly larger than the infection + vonoprazan group (*p = 0.008). Decrease in NHPH in the vonoprazan-treated mice, but significant interaction was found between infection and administered agents in NHPHs (F = 7.17; p = 0.008).