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. 2022 Jul 22;13:692437. doi: 10.3389/fphar.2022.692437

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Copyright © 2022 Nakamura, Murasato, Øverby, Kodama, Michimae, Sasaki, Flahou, Haesebrouck, Murayama, Takahashi, Uchida, Suzuki and Matsui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Localization of apoptotic NHPHs in the infection group by acid suppressants by the TUNEL method X 200. (A) In the infection-alone group, no apoptosis was detected. (B) In the vonoprazan-treated group, apoptotic NHPHs were detected within the intracellular canaliculi of the parietal cells. (C) In the lansoprazole-treated group, many NHPHs were found, but no apoptotic reaction was recognized. (D) In the famotidine-treated group, NHPHs in the parietal cells were negative for the TUNEL reaction.