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. 2022 Jul 22;13:692437. doi: 10.3389/fphar.2022.692437

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Copyright © 2022 Nakamura, Murasato, Øverby, Kodama, Michimae, Sasaki, Flahou, Haesebrouck, Murayama, Takahashi, Uchida, Suzuki and Matsui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantitative analysis of all NHPHs and apoptotic NHPHs by using acid suppressants by immunohistochemistry. (A) Significant difference was found between infection alone and administered agents in the NHPH number (F = 6.14; p = 0.005 by one-way ANOVA). Post hoc analyses (Bonferroni correction) revealed that the infection-alone group is significantly larger than the infection + vonoprazan group (*p = 0.004). (B) Significant difference was found between infection alone and administered agents in the TUNEL-positive NHPH number (F = 28.1; p < 0.001 by one-way ANOVA). Post hoc analyses (Bonferroni correction) revealed that the infection + vonoprazan group is significantly larger than the infection-alone group (**p < 0.001).