Table 14.
Concentration of 8-isoprostane in A549 cells after 24 h and 72 h incubation with 20 nm and 100 nm Au NPs (pcs/mL).
| Control or pcs/mL | 24 h∗ 8-isoprostane (pg/mL) |
72 h 8-isoprostane (pg/mL) |
||
|---|---|---|---|---|
| Control• | 295.43 (288.69-314.6) | 290.330 (279.376-302.673) | ||
| 20 nm | 100 nm | 20 nm | 100 nm | |
| 1.6×107 | 265.67 (258.35-276.47) | 323.37∗∗¥¥ (297.2-343.35) | ||
| 1.6×109 ¥ | 248.41•• (242.38-257.18) | 277.91 (273.64-293.70) | 270.91 (266.95-285.48) | 259.52• (253.79-265.67) |
| 1.6×1011 | 258.35• (256.03-266.95) | 302.67∗∗ (288.69-316.72) | ||
Results are expressed as median (lower quartile–upper quartile). •,••Significance between control cells and cells incubated with NPs of a given size and concentration (•P < 0.05, ••P < 0.01). ∗∗Significance over time (between 24 h and 72 h) in cells incubated with NPs of a given size and concentration (∗∗P < 0.01). ¥¥: Significance between cells incubated with 100 nm NPs at the concentrations of 1.6 × 109 pcs/mL and 1.6 × 107 pcs/mL (¥¥P < 0.01).