Table 15.
Concentration of protein carbonyls in A549 cells after 24 h and 72 h incubation with 20 nm and 100 nm Au NPs (pcs/mL).
| Control or pcs/mL | 24 h∗ Protein carbonyls (nmol/mg proteins) |
72 h Protein carbonyls (nmol/mg proteins) |
||
|---|---|---|---|---|
| Control• | 74.93 (70.24-82.42) | 384.535∗∗ (374.036-393.722) | ||
| 20 nm | 100 nm | 20 nm | 100 nm | |
| 1.6 × 107 | 72 (2.45 - 77.72) | 111.92•∗¥¥ (101.48-116.4) | ||
| 1.6 × 109 + ¥ | 56.83 (51.58-62.95) | 75.83 (69.26-81.66) | 243.45∗∗ (232.86-256.68) | 402.31∗ (397.03-412.87) |
| 1.6 × 1011 | 100.14+++ (95.22-106.71) | 256.17∗∗ (251.42-268.02) | ||
Results are expressed as median (lower quartile–upper quartile). •Significance between control cells and cells incubated with NPs of a given size and concentration (•P < 0.05). ∗,∗∗Significance over time (between 24 h and 72 h) in cells incubated with NPs of a given size and concentration (∗P < 0.05, ∗∗P < 0.01). +++: Significance between cells incubated with 20 nm NPs at concentrations of 1.6 × 109 pcs/mL and 1.6 × 1011 pcs/mL (+++P < 0.001). ¥¥: Significance between cells incubated with 100 nm NPs at concentrations of 1.6 × 107 pcs/mL and 1.6 × 109 pcs/mL (¥¥P < 0.01).