Table 8.
Concentration of 8-isoprostane in A375 cells after 24 h and 72 h incubation with 20 nm and 100 nm Au NPs (pcs/mL).
| Control or pcs/mL | 24 h∗ 8-isoprostane (pg/mL) |
72 h 8-isoprostane (pg/mL) |
||
|---|---|---|---|---|
| Control • | 238.6 (226.63–246.35) | 238.6 (230.7–242.38) | ||
| 20 nm | 100 nm | 20 nm | 100 nm | |
| 1.6 × 107 | 252.68 (243.36–264.4) | 245.34 (236.78–256.03) | ||
| 1.6 × 109+ | 239.53 (226.63–244.34) | 240.47 (227.42–248.41) | 276.47•∗ (257.18–283.92) | 246.35 (239.53–257.18) |
| 1.6 × 1011 | 263.16•+ (250.52–276.47) | 232.39 (225.06–234.11) | ||
Results are expressed as median (lower quartile–upper quartile). •Significance between control cells and cells incubated with NPs of a given size and concentration (•P < 0.05). ∗Significance over time (between 24 h and 72 h) in cells incubated with NPs of a given size and concentration (∗P < 0.05). +: Significance between cells incubated with 20 nm NPs at the concentrations of 1.6 × 109 pcs/mL and 1.6 × 1011 pcs/mL (+P < 0.05).