Table 9.
Concentration of protein carbonyls in A375 cells after 24 h and 72 h incubation with 20 nm and 100 nm Au NPs (pcs/mL).
| Control or pcs/mL | 24 h∗ Protein carbonyls (nmol/mg proteins) |
72 h Protein carbonyls (nmol/mg proteins) |
||
|---|---|---|---|---|
| Control • | 201.4 (197.1-205.7) | 1346.7∗∗ (1331.1-1365.8) | ||
| 20 nm | 100 nm | 20 nm | 100 nm | |
| 1.6 × 107 | 1006.6••• (1000.9-1020.8) | 1292.7∗∗ (1277-1303.7) | ||
| 1.6 × 109 | 739.3 (732.8-746.0) | 1036.4••• (1023.9-1040.2) | 1750.1∗ (1742.2-1756.5) | 1329.8 (1318.4-1344) |
| 1.6 × 1011 | 462.3 (454.0-470.6) | 1358.0∗ (1343.5-1362.4) | ||
Results are expressed as median (lower quartile–upper quartile). •••Significance between control cells and cells incubated with NPs of a given size and concentration (•••P < 0.001). ∗, ∗∗Significance over time (between 24 h and 72 h) in cells incubated with NPs of a given size and concentration (∗P < 0.05, ∗∗P < 0.01).