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Generation and administration of CAR T-cells in patients with cancer. (A) T cells are collected from patients’ blood via apheresis. They are genetically engineered to express CAR and cultured ex vivo for expansion. CAR T-cells are then administered to patients. The cells identify their target and kill the tumor cells expressing that target. (B) Illustration of basic structure of four generations of CAR T-cells. Created with BioRender.com.
