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. 2022 Jul 22;13:925985. doi: 10.3389/fimmu.2022.925985

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Copyright © 2022 Jogalekar, Rajendran, Khan, Dmello, Gangadaran and Ahn

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CAR-T EV-based therapy for cancer CAR-T EVs containing catalytic proteins (perforin and granzyme B). CAR-T EVs’ interacting and internalizing into cancer cells and leading to apoptotic blebbing and apoptosis. Created with BioRender.com.