Title	Maximum tolerated dose
Number of patients screened	24
Number of patients enrolled	20
Number of patients evaluable for toxicity	20
Number of patients evaluated for efficacy	19
Evaluation method	Safety assessment was made using CTCAE v4.0. Efficacy assessment was based on pathological response evaluated by post–operative pathological staging and Neoadjuvant Rectal (NAR) score to compare the initial clinical and final pathological staging. The TNM AJCC 7th edition was used to determine the pathological staging.
Response assessment CR	n = 7 (37.8%)
Response assessment other	n = 9 (47.4%)