Table 2.

Biomarker levels at baseline and post-treatment. Fold change (post-chemo/baseline) was calculated for each patient and averaged.

Biomarker	Unit	Baseline (n = 18)	Post-chemo (n = 12)	Fold change: median (range)
Ang2	pg/mL	396.65 (170.06-959.7)	375.9 (184.69-827.5)	1.01 (0.48-1.89)
BMP9	pg/mL	87.64 (37.39-382.25)	163.49 (41.34-318.91)	1.58 (0.89-5.53)
CD73	pg/mL	0.25 (0.01-23.29)	0.39 (0.02-9.91)	1.12 (0.03-143.52)
GP130	ng/mL	279.05 (187.10-432.95)	315.30 (208.00-468.15)	1.1 (0.5-2)
HGF	pg/mL	139.48 (47.19-292.9)	160.83 (34.26-357.6)	1.1 (0.28-2.05)
ICAM1	ng/mL	449.65 (284.10-889.05)	436.50 (310.55-649.90)	1.07 (0.89-1.3)
IL6	pg/mL	2.63 (0.49-6.47)	1.98 (0.4-6.9)	1.31 (0.13-3.37)
IL6R	ng/mL	35.13 (23.08-48.36)	39.88 (23.06-56.01)	1.03 (0.93-1.51)
OPN	ng/mL	87.35 (43.96-235.39)	93.41 (67.89-205.43)	1.08 (0.65-1.75)
PDGFAA	pg/mL	126.06 (7.84-1714.88)	291.19 (69.55-3182.5)	2.55 (0.36-22.16)
PDGFBB	pg/mL	515.92 (54.34-10325)	1893.75 (191.43-10015)	2.83 (0.23-13.07)
PlGF	pg/mL	11.8 (4.72-24.7)	16.03 (9.43-32.54)	1.5 (0.9-2.41)
SDF1	ng/mL	1.62 (0.58-3.17)	1.79 (0.25-4.38)	1.16 (0.31-3.07)
TGFb1	ng/mL	17.17 (9.72-107.88)	26.41 (11.93-114.68)	1.37 (0.33-6.22)
TGFb2	pg/mL	55.71 (36.04-93.22)	79.32 (32.75-194.47)	1.28 (0.35-3.18)
TGFbR3	ng/mL	125.93 (79.32-171.63)	120.68 (84.08-194.68)	1.18 (0.63-1.45)
TIMP1	ng/mL	61.58 (40.56-112.85)	83.79 (56.82-139.55)	1.33 (0.93-2.22)
TSP2	ng/mL	131.70 (64.05-275.30)	189.15 (115.88-242.48)	1.13 (0.72-2.15)
VCAM1	ug/mL	1.97 (1.49-3.40)	2.37 (1.50-3.02)	0.92 (0.84-1.68)
VEGF	pg/mL	38.55 (18.84-109.3)	46.59 (23.11-77.54)	1.31 (0.24-1.88)
VEGFC	pg/mL	574.06 (321.22-2488.03)	773.27 (378.33-2669.72)	1.25 (0.39-3.58)
VEGFD	ng/mL	1.12 (0.81-2.79)	1.27 (1.05-2.96)	1.15 (0.75-2.67)
VEGFR1	pg/mL	63.14 (13.55-98.42)	67.4 (29.2-146.96)	1.15 (0.45-1.83)
VEGFR2	ng/mL	4.84 (1.13-7.28)	4.82 (3.08-7.30)	0.97 (0.7-1.25)
VEGFR3	ng/mL	164.04 (63.40-285.03)	245.03 (150.23-342.40)	1.18 (0.94-1.97)