Table 3.
Burden to healthcare systems.
| Design | Cohort | N | Cost per FN episode | Total cost | Risk factors for higher cost | Ref |
|---|---|---|---|---|---|---|
| Pediatric pts | ||||||
| Retrospective analysis of NIS, 2007-2014 | Pediatric pts with cancer hospitalized for FN | 104 315 hospitalizations for FN | 2007: $8771a 2014: $11 202a |
— | Age 10-14 and 15-19 years versus 0-4 years (P < .001) Leukemia primary diagnosis (P < .001) Medicare/Medicaid insurance (P = .001) or other insurance (P < .001) versus private insurance Comorbid infections (sepsis, pneumonia, viral URI, meningitis, gastroenteritis, mycosis, and skin and subcutaneous infections; all P < .001) Western region (P = .03) |
Lekshminarayanan et al31 |
| Retrospective analysis of NIS and KID, 2012 | Pediatric (<18 years) and adult (≥18 years) pts with cancer hospitalized for neutropenia | 16 859 pediatric hospitalizations for neutropenia | $20 366b | $439 million (27.2% of all cancer-related hospitalization costs) | Leukemia primary diagnosis | Tai et al32 |
| Cross-sectional analysis of KID, 2012 | Pediatric pts with cancer admitted for FN | 120 675 hospital discharges among pediatric pts care with cancer | $65 536b | ~$881 million | — | Mueller et al34 |
| Cross-sectional analysis of KID, 2009 | Pediatric pts with cancer admitted for FN | 110 967 hospital discharges among pediatric pts with cancer | $52 160b | ~$587 million | — | Mueller et al35 |
| Adult and elderly pts | ||||||
| Retrospective cohort study of Medicare 20% sample data from the CMS, 2007-2015 | Elderly pts (aged ≥66 years) with breast cancer, lung cancer, or NHL | 2138 pts with breast cancer 3521 pts with lung cancer 2862 pts with NHL |
Breast cancer: $13 457b Lung cancer: $15 409b NHL: $16 009b |
— | — | Li et al37 |
| Retrospective analysis of NIS and KID, 2012 | Pediatric (<18 years) and adult (≥18 years) pts with cancer hospitalized for neutropenia | 91 560 adult hospitalizations for neutropenia | $20 778b | $2.3 billion (8.3% of all cancer-related hospitalization costs) | Leukemia primary diagnosis | Tai et al32 |
| Retrospective analysis of NIS, 2009-2011 | Adult pts with breast cancer hospitalized for FN | 26 628 FN hospitalizations | $37 087b | — | — | Pathak et al20 |
Median.
Mean.
CMS, Centers for Medicare & Medicaid Services; FN, febrile neutropenia; KID, Kids’ Inpatient Database; NHL, non-Hodgkin lymphoma; NIS, National Inpatient Sample; pts, patients; URI, upper respiratory infection.